Impact of early detection of acute invasive fungal rhinosinusitis in immunocompromised patients
| Autor: | Wilma Terezinha Anselmo-Lima, Francesca M. Faria, Fabiana Cardoso Pereira Valera, Ricardo Miranda Lessa, Danielle Leite Cunha de Queiroz, Marcelo G. J. Leite, Edwin Tamashiro, Belinda Pinto Simões, Mariana L. C. Silveira, Rodrigo L. Nogueira |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Rhinosinusitis Biopsy Frozen-section biopsy Acute invasive fungal rhinosinusitis Frozen Sections Sinusitis Child Nose Accuracy Rhinitis Paraffin Embedding medicine.diagnostic_test Mortality rate Middle Aged Survival Rate Infectious Diseases medicine.anatomical_structure Child Preschool Cohort Female Research Article Adult medicine.medical_specialty Adolescent Tertiary referral hospital Sensitivity and Specificity lcsh:Infectious and parasitic diseases Immunocompromised Host Internal medicine medicine Humans lcsh:RC109-216 Paraffin-embedded paraffin Aged Retrospective Studies business.industry Fungi Infant Retrospective cohort study Endoscopy medicine.disease Early Diagnosis business Invasive Fungal Infections |
| Zdroj: | BMC Infectious Diseases BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-6 (2019) |
| ISSN: | 1471-2334 |
| Popis: | Background Early diagnosis of acute invasive fungal rhinosinusitis (AIFRS) is vital to improving outcomes in immunocompromised patients. This study evaluated the impact of a systematic protocol with nasal endoscopy and biopsies to early detect AIFRS in immunocompromised patients. Additionally, we compared the accuracy of frozen-section biopsy and culture with formalin-fixed paraffin-embedded (FFPE) biopsy. Methods Retrospective cohort in a Tertiary Referral Hospital. Patients with the suspected diagnosis of AIFRS were evaluated following a standardized protocol, including serial nasal endoscopies and biopsies when necessary. The sensitivity and specificity of frozen-section biopsy and culture were also compared with FFPE. Results The mortality rate related to AIFRS of this standardized cohort (13/43) was 30.2%. Better outcomes were observed in patients with disease limited to the turbinates and in those with higher peripheral neutrophils count. Frozen-section biopsy positivity correlated with FFPE findings for fungi detection (p-value |
| Databáze: | OpenAIRE |
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