Neurocognitive Phenotyping of HIV in the Era of Antiretroviral Therapy
| Autor: | Robert H. Paul |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male AIDS Dementia Complex Human immunodeficiency virus (HIV) Bioinformatics medicine.disease_cause Article 03 medical and health sciences Treatment status 0302 clinical medicine Risk Factors Virology medicine Humans 030212 general & internal medicine Vascular Diseases Cerebrum Subtypes of HIV Aged Aged 80 and over business.industry Cognition Antiretroviral therapy Additional research 030104 developmental biology Infectious Diseases Phenotype Nervous System Diseases business Neurocognitive Hiv disease |
| Zdroj: | Curr HIV/AIDS Rep |
| ISSN: | 1548-3576 |
| Popis: | PURPOSE OF REVIEW: The overarching goal of the current paper is to examine the empirical basis for neurocognitive phenotyping of HIV. RECENT FINDINGS: The pattern of cognitive symptoms associated with HIV has traditionally been referred to as a “subcortical” phenotype. Recent concern has been raised that the neurocognitive phenotype in the post-ART era has changed to reflect the addition of cortical features, suggestive of synergistic age-related neurodegeneration. Empirical evidence reviewed in this paper suggests that, when present, HIV-related cognitive impairment in the post-ART era remains “subcortical” in nature, regardless of advanced age or treatment status. Persistent neurocognitive impairment among virally suppressed individuals may reflect a combination of HIV disease factors, pre-existing risk factors, and/or emergent health comorbidities such as cerebrovascular disease in older people living with HIV. SUMMARY: An entrenchment of the “subcortical” neurocognitive phenotype of HIV appears to be unfolding in the post-ART era. Whether additional neurocognitive subtypes of HIV exist in the current era requires additional research utilizing harmonized test protocols and advanced computational methods capable of deep phenotyping. Recommendations from other neurological disorders are provided. |
| Databáze: | OpenAIRE |
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