International Multicenter Analysis of Brain Structure Across Clinical Stages of Parkinson's Disease

Autor: Odile A. van den Heuvel, Reinhold Schmidt, Boris A. Gutman, Daniel Weintraub, Corey T. McMillan, Gianfranco Spalletta, Ines Debove, Tim J. Anderson, Max A. Laansma, Petra Schwingenschuh, Cristiane S. Rocha, Tracy R. Melzer, Francesca Assogna, John C. Dalrymple-Alford, Mario Rango, Michiel F. Dirkx, Lucas S.R. Santos, Laura M. Parkes, Rachel Guimaraes, Hedley C. A. Emsley, Toni L. Pitcher, Roland Wiest, Fernando Cendes, Henk W. Berendse, Clarissa L. Yasuda, Gaëtan Garraux, Joanna Bright, Jiun-Jie Wang, Neda Jahanshad, Johannes C. Klein, Katherine Baquero, Tyler Ard, Ysbrand D. van der Werf, Sarah Al-Bachari, Jamie C. Blair, Rick C. Helmich, Fabrizio Piras, Chris Vriend, Jason Druzgal, Letizia Squarcina, Paul M. Thompson, Kathleen L. Poston, Clare E. Mackay, Rob M.A. de Bie, Christian Rummel, Letícia F. Ribeiro
Přispěvatelé: Neurology, ANS - Neurodegeneration, APH - Aging & Later Life, Amsterdam Neuroscience - Neurodegeneration, Anatomy and neurosciences, Psychiatry, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, Amsterdam Neuroscience - Brain Imaging, Amsterdam Neuroscience - Systems & Network Neuroscience
Rok vydání: 2021
Předmět:
Zdroj: Movement Disorders, 36, 11, pp. 2583-2594
Laansma, M A, Bright, J K, Al-Bachari, S, Anderson, T J, Ard, T, Assogna, F, Baquero, K A, Berendse, H W, Blair, J, Cendes, F, Dalrymple-Alford, J C, de Bie, R M A, Debove, I, Dirkx, M F, Druzgal, J, Emsley, H C A, Garraux, G, Guimarães, R P, Gutman, B A, Helmich, R C, Klein, J C, Mackay, C E, McMillan, C T, Melzer, T R, Parkes, L M, Piras, F, Pitcher, T L, Poston, K L, Rango, M, Ribeiro, L F, Rocha, C S, Rummel, C, Santos, L S R, Schmidt, R, Schwingenschuh, P, Spalletta, G, Squarcina, L, van den Heuvel, O A, Vriend, C, Wang, J-J, Weintraub, D, Wiest, R, Yasuda, C L, Jahanshad, N, Thompson, P M, van der Werf, Y D & ENIGMA-Parkinson's Study 2021, ' International Multicenter Analysis of Brain Structure Across Clinical Stages of Parkinson's Disease ', Movement Disorders, vol. 36, no. 11, pp. 2583-2594 . https://doi.org/10.1002/mds.28706
Movement disorders, 36(11), 2583-2594. John Wiley and Sons Inc.
Movement Disorders, 36, 2583-2594
Laansma, Max A; Bright, Joanna K; Al-Bachari, Sarah; Anderson, Tim J; Ard, Tyler; Assogna, Francesca; Baquero, Katherine A; Berendse, Henk W; Blair, Jamie; Cendes, Fernando; Dalrymple-Alford, John C; de Bie, Rob M A; Debove, Ines; Dirkx, Michiel F; Druzgal, Jason; Emsley, Hedley C A; Garraux, Gäetan; Guimarães, Rachel P; Gutman, Boris A; Helmich, Rick C; ... (2021). International Multicenter Analysis of Brain Structure Across Clinical Stages of Parkinson's Disease. Movement disorders, 36(11), pp. 2583-2594. Wiley-Blackwell 10.1002/mds.28706
Movement Disorders, 36(11), 2583-2594. John Wiley and Sons Inc.
ISSN: 0885-3185
DOI: 10.1002/mds.28706
Popis: Contains fulltext : 244253.pdf (Publisher’s version ) (Open Access) BACKGROUND: Brain structure abnormalities throughout the course of Parkinson's disease have yet to be fully elucidated. OBJECTIVE: Using a multicenter approach and harmonized analysis methods, we aimed to shed light on Parkinson's disease stage-specific profiles of pathology, as suggested by in vivo neuroimaging. METHODS: Individual brain MRI and clinical data from 2357 Parkinson's disease patients and 1182 healthy controls were collected from 19 sources. We analyzed regional cortical thickness, cortical surface area, and subcortical volume using mixed-effects models. Patients grouped according to Hoehn and Yahr stage were compared with age- and sex-matched controls. Within the patient sample, we investigated associations with Montreal Cognitive Assessment score. RESULTS: Overall, patients showed a thinner cortex in 38 of 68 regions compared with controls (d(max) = -0.20, d(min) = -0.09). The bilateral putamen (d(left) = -0.14, d(right) = -0.14) and left amygdala (d = -0.13) were smaller in patients, whereas the left thalamus was larger (d = 0.13). Analysis of staging demonstrated an initial presentation of thinner occipital, parietal, and temporal cortices, extending toward rostrally located cortical regions with increased disease severity. From stage 2 and onward, the bilateral putamen and amygdala were consistently smaller with larger differences denoting each increment. Poorer cognition was associated with widespread cortical thinning and lower volumes of core limbic structures. CONCLUSIONS: Our findings offer robust and novel imaging signatures that are generally incremental across but in certain regions specific to disease stages. Our findings highlight the importance of adequately powered multicenter collaborations. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Databáze: OpenAIRE
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