Influence of biomaterials on scintigraphic diagnosis of periprosthetic infections. Ceftizoxime-99m technetium model
| Autor: | Ivana Duval Araújo, Valbert Nascimento Cardoso, Marco Antônio Percope de Andrade, Simone Odília Fernandes Diniz, Isabella Kuniko Tavares Magalhães Takenaka, Jefferson Soares Leal, Bruno Jannotti Pádua, André Moreira Castilho, Luiz Eduardo Moreira Teixeira |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Prosthesis-Related Infections
Time Factors RD1-811 Radionuclide imaging Periprosthetic chemistry.chemical_element Biocompatible Materials Scintigraphy Technetium 030218 nuclear medicine & medical imaging Random Allocation 03 medical and health sciences 0302 clinical medicine Reference Values Ceftizoxime Animals Medicine Ceftizoxima-99m Rats Wistar Biocompatible materials Radionuclide Imaging Titanium 030222 orthopedics medicine.diagnostic_test business.industry fungi Significant difference technology industry and agriculture Reproducibility of Results Infecções periprotéticas Organotechnetium Compounds Stainless Steel Biocompatible material Biomateriais Rats Radioactivity chemistry Prosthesis-related infections Surgery Radiopharmaceuticals Nuclear medicine business medicine.drug |
| Zdroj: | Repositório Institucional da UFMG Universidade Federal de Minas Gerais (UFMG) instacron:UFMG Acta Cirúrgica Brasileira v.33 n.1 2018 Acta Cirúrgica Brasileira Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC Acta Cirurgica Brasileira, Vol 33, Iss 1, Pp 14-21 (2018) Acta Cirurgica Brasileira, Volume: 33, Issue: 1, Pages: 14-21, Published: JAN 2018 |
| Popis: | Purpose: To compare the influence of two metallic implants in the diagnosis of periprosthetic infection using 99m technetium-labeled ceftizoxime. Methods: Twenty rats were randomly divided into four groups, which received sterile and contaminated titanium and stainless steel implants. After 3 weeks, scintilographic images were obtained using a gamma chamber. Radioactivity counts were obtained for the region of interest (ROI) on the operated and non-operated paws. Results: Groups A, B, and C showed homogenous distribution of the radiopharmaceutical. Hyper uptake was observed in the operated paw from group D. The ROI target count was higher in the two groups with stainless steel implants. Among the control groups, the count was higher in the stainless steel group. Furthermore, among the contaminated groups, the uptake was higher in the stainless steel group, with a significant difference. The target: non-target ratio was significantly lower in the control and contaminated groups with both titanium and stainless steel, but the comparison between control groups and contaminated groups was only significant in the former. The cpm/g observed after a decay of 48h showed statistically significant differences between groups. Conclusion: Different biomaterials used in implants have an influence on the results of scintigraphy with 99mTc-CFT. |
| Databáze: | OpenAIRE |
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