The diagnostic and prognostic role of neutrophil-to-lymphocyte ratio in COVID-19: a systematic review and meta-analysis

Autor: Andrew Purcell, Mohammed A. Yousef, Mohamed Gomaa Kamel, Amr Naguib, Mohamed Wagih, Hany Mahmoud Yassin, Ehab Farag, Mohamed Helmy, Mohamed Elayashy, Fatma Abd-Elshahed Abd-Elhay, Haytham Zien Algameel, Mohamed Hamza, Ahmed Abdelaal Ahmed Mahmoud M Alkhatip
Rok vydání: 2021
Předmět:
Adult
Male
0301 basic medicine
Oncology
medicine.medical_specialty
Coronavirus disease 2019 (COVID-19)
Neutrophils
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Sensitivity and Specificity
Severity of Illness Index
Pathology and Forensic Medicine
Leukocyte Count
03 medical and health sciences
0302 clinical medicine
Internal medicine
Severity of illness
Genetics
medicine
Humans
In patient
Lymphocyte Count
Neutrophil to lymphocyte ratio
Molecular Biology
Aged
business.industry
fungi
Advanced stage
COVID-19
Middle Aged
Prognosis
Neutrophil-to-lymphocyte ratio – covid-19 – coronavirus – diagnosis – prognosis – systematic review – meta-analysis
030104 developmental biology
030220 oncology & carcinogenesis
Meta-analysis
Molecular Medicine
Biomarker (medicine)
Female
business
Research Article
Meta-Analysis
Zdroj: Expert Review of Molecular Diagnostics
article-version (VoR) Version of Record
ISSN: 1744-8352
1473-7159
DOI: 10.1080/14737159.2021.1915773
Popis: Background: The world urgently requires surrogate markers to diagnose COVID-19 and predict its progression. The severity is not easily predicted via currently used biomarkers. Critical COVID‐19 patients need to be screened for hyperinflammation to improve mortality but expensive cytokine measurement is not routinely conducted in most laboratories. The neutrophil-to-lymphocyte ratio (NLR) is a novel biomarker in patients with various diseases. We evaluated the diagnostic and prognostic accuracy of the NLR in COVID-19 patients. Methods: We searched for relevant articles in seven databases. The quantitative analysis was conducted if at least two studies were evaluating the NLR role in COVID-19. Results: We included 8,120 individuals, including 7,482 COVID-19 patients, from 32 articles. Patients with COVID-19 had significantly higher levels of NLR compared to negative individuals. Advanced COVID-19 stages had significantly higher levels of NLR than earlier stages. Expert Opinion: We found significantly higher levels of NLR in advanced stages compared to earlier stages of COVID-19 with good accuracy to diagnose and predict the disease outcome, especially mortality prediction. A close evaluation of critical SARS-CoV-2 patients and efficient early management are essential measures to decrease mortality. NLR could help in assessing the resource allocation in severe COVID-19 patients even in restricted settings.
Databáze: OpenAIRE
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