Mechanism of antibiotic efflux in Gram-negative bacteria
| Autor: | Ganesh Krishnamoorthy, Sze Yi Lau, Elena B. Tikhonova, Kelly L. Stratton, Helen I. Zgurskaya |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Gram-negative bacteria
biology medicine.drug_class Chemistry Antibiotics Biological Transport Active biology.organism_classification Antimicrobial Anti-Bacterial Agents Multiple drug resistance Membrane Biochemistry Drug Resistance Multiple Bacterial Gram-Negative Bacteria medicine Animals Humans Efflux Multidrug Resistance-Associated Proteins Bacterial outer membrane Bacteria |
| Zdroj: | Frontiers in bioscience : a journal and virtual library. 8 |
| ISSN: | 1093-9946 |
| Popis: | Active efflux of antibiotics mediated by multidrug transporters is a mechanistic basis of multidrug resistance in bacteria. The most versatile multidrug transporters are those found in Gram-negative bacteria. They have a high level of constitutive expression and provide an immediate response to structurally diverse antimicrobial agents including clinically important antibiotics. The versatility and efficiency of multidrug transporters in Gram-negative bacteria heavily depend on coupling of drug efflux with the transport across the outer membrane. The coupling is achieved through the assembly of multi-component protein complexes that span both the inner and the outer membranes of Gram-negative bacteria. In this review we discuss the mechanistic and structural features of multidrug efflux complexes with the major focus on the tight coupling of drug efflux with transport across the outer membrane. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|