Protective effect of dietary flavonoid quercetin against lipemic-oxidative hepatic injury in hypercholesterolemic rats

Autor:	Gamil M. Abd-Allah, Amr D. Mariee, Hesham A. El-Beshbishy
Rok vydání:	2012
Předmět:	Male Lipid Peroxides medicine.medical_specialty Antioxidant medicine.medical_treatment Hypercholesterolemia Flavonoid Pharmaceutical Science Context (language use) Oxidative phosphorylation Nitric Oxide Antioxidants Nitric oxide Cholesterol Dietary Rats Sprague-Dawley chemistry.chemical_compound Internal medicine Drug Discovery medicine Animals heterocyclic compounds Triglycerides Lipoprotein cholesterol Pharmacology chemistry.chemical_classification Anticholesteremic Agents Cholesterol HDL Cholesterol LDL General Medicine Glutathione Rats Oxidative Stress Cholesterol Endocrinology Liver Complementary and alternative medicine chemistry Dietary Supplements Molecular Medicine Quercetin Oxidation-Reduction Dietary Flavonoid
Zdroj:	Pharmaceutical Biology. 50:1019-1025
ISSN:	1744-5116 1388-0209
DOI:	10.3109/13880209.2012.655424
Popis:	Quercetin, a dietary-derived flavonoid, is ubiquitous in fruits and vegetables and plays important roles in human health by virtue of its antioxidant activity.This study was conducted to investigate the possible modulatory effect of quercetin against hepatic lipemic-oxidative injury in rats fed with a high cholesterol diet (HCD), and to highlight the underlying mechanisms of such effect.Different groups of male Sprague-Dawley rats were used; one group was treated by gavage with HCD cocktail (1 mL/100 g) whereas another group was orally administered HCD-enriched with quercetin (15 mg/kg). Corresponding control animals were also used.Quercetin administration significantly decreased liver triglycerides (24%), liver total cholesterol (TC) (22%), serum TC (20%), serum low-density lipoprotein cholesterol (31%), and duplicated serum high-density lipoprotein cholesterol (HDL-C). This study also revealed that quercetin administration significantly reduced the activity of serum alanine aminotransferase (41%), aspartate aminotransferase (51%), and γ-glutamyl transpeptidase (G-GT) (35%). Significant inhibition of thiobarbituric acid-reacting substances (40%), together with a valuable enhancement of reduced glutathione (GSH) content (53%) in the liver homogenates, was observed. In addition, quercetin-treated hypercholesterolemic animals exhibited a reasonable improvement of hepatic antioxidant enzymes. Moreover, serum and liver content of nitric oxide (NO) were markedly decreased in this model (26 and 25%, respectively), and were almost normalized following quercetin administration.These data revealed that quercetin has the ability to ameliorate HCD-induced lipemic-oxidative injury in rat liver possibly through its antioxidant potential and/or increased NO bioavailability.
Databáze:	OpenAIRE
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