Comparison between fractional Co2 laser-triamcinolone injection combination therapy and triamcinolone injection monotherapy for keloid
| Autor: | Dwi Murtiastutik, Putri Hendria Wardhani, Muhammad Yulianto Listiawan, Willy Sandhika, Brama Rachmantyo |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
therapy
medicine.medical_specialty Co2 laser Triamcinolone acetonide Combination therapy Triamcinolone Injection business.industry Urology Dermatology triamcinolone lcsh:RL1-803 medicine.disease keloid laser medicine.anatomical_structure Keloid Dermis lcsh:Dermatology medicine Adjuvant therapy CO2 Fibroblast business medicine.drug |
| Zdroj: | Dermatology Reports, Vol 11, Iss 1s (2019) |
| ISSN: | 2036-7406 2036-7392 |
| Popis: | The histopathologic view of keloid shows dense fibroblasts and bundles of collagen throughout dermis. Treatment that completely cure keloid still not exist, although there are many treatment options. The monotherapy fractional CO2 laser shows good results, but is still as an adjuvant therapy. Fractional CO2 laser affects fibroblast and its functions in producing collagen. The combination therapy will combine the selective phototermolysis effect of CO2 lasers with antimitotic and antiinflammatory effects of corticosteroids. This study was an open trial with parallel design that compared fractional CO2 laser-intralesional triamcinolone acetonide combination therapy (treatment group) and intralesional triamcinolone acetonide (control group) in keloid patients with collagen density as evaluation parameter. The dose of triamcinolone was 10 mg/ml of 0.05-0.1 ml/cm2 of keloid. Fractional CO2 laser energy setting was 10-20 mJ. The decrease of collagen density in control and treatment group was significant (p=0.008 and p=0.001), although the decrease difference between control and treatment group was not significant (p=0.328). The collagen density that decrease in a shorter time shows that fractional CO2 laser could be a good combination therapy. |
| Databáze: | OpenAIRE |
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