Longevity-associated mitochondrial DNA 5178 C/A polymorphism is associated with fasting plasma glucose levels and glucose tolerance in Japanese men
| Autor: | Masao Satoh, Kanako Sekiguchi, Yoshiko Uchida, Koji Teruya, Matsuko Harada, Masao Yoshida, Yutaka Takashima, Akatsuki Kokaze, Yumi Masuda, Naomi Matsunaga, Mamoru Ishikawa, Ryuji Makita |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Mitochondrial DNA media_common.quotation_subject Longevity Type 2 diabetes Biology DNA Mitochondrial Polymorphism Single Nucleotide chemistry.chemical_compound Japan Internal medicine Genotype medicine Humans Molecular Biology media_common Genetics Plasma glucose Fasting Cell Biology Glucose Tolerance Test Middle Aged Japanese population medicine.disease Mitochondria Endocrinology chemistry Molecular Medicine Body mass index Cytosine |
| Zdroj: | Mitochondrion. 5:418-425 |
| ISSN: | 1567-7249 |
| DOI: | 10.1016/j.mito.2005.09.001 |
| Popis: | Mitochondrial DNA 5178 cytosine/adenine (Mt5178 C/A) polymorphism is reportedly associated with longevity in the Japanese population, and the Mt5178A genotype may resist the onset of type 2 diabetes. To investigate whether Mt5178 C/A polymorphism is associated with glucose tolerance, we conducted a cross-sectional study using the 75-g oral glucose tolerance test (OGTT) in which non-diabetic Japanese male subjects were classified into three subgroups by body mass index (BMI): BMI22 (n=91); 22or =BMI25 (n=138); and BMIor =25 (n=67). The frequency of Mt5178A was significantly lower among 'BMI22' subjects exhibiting impaired fasting glucose and impaired glucose tolerance than among those with normal glucose tolerance. In the 'BMI22' group, fasting plasma glucose (FPG) levels and plasma glucose levels at 60 and 120 min after glucose load (OGTT-1h and OGTT-2h, respectively) were significantly lower in the Mt5178A genotype than in the Mt5178C genotype. After adjusting for age, BMI, habitual smoking, habitual drinking and family history of diabetes, FPG levels and OGTT-2h levels were still significantly lower in the Mt5178A genotype than in the Mt5178C genotype. However, after adjusting for covariates, in both the '22or =BMI25' and 'BMIor =25' groups, FPG levels were significantly higher in the Mt5178A genotype than in the Mt5178C genotype. Differences in the effect of alcohol consumption on FPG levels and glucose tolerance between the Mt5178 C/A genotypes were observed. The present results suggest that Mt5178 C/A polymorphism may be associated with FPG levels and glucose tolerance in middle-aged Japanese men. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect