Eccentric-focused rehabilitation promotes myelin plasticity in individuals with chronic, incomplete spinal cord injury
| Autor: | Keith R. Lohse, Bimal Lakhani, Dana M. McTigue, Lara A. Boyd, John L.K. Kramer, Petra Schmalbrock, Huyen T. Nguyen, D. Michele Basso, Hanwen Liu, Michael V. Knopp, Timothy D. Faw |
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| Rok vydání: | 2020 |
| Předmět: |
Nervous system
0303 health sciences medicine.medical_specialty Rehabilitation business.industry medicine.medical_treatment medicine.disease Spinal cord 03 medical and health sciences Myelin 0302 clinical medicine medicine.anatomical_structure Physical medicine and rehabilitation medicine Biomarker (medicine) Eccentric Motor learning business Spinal cord injury 030217 neurology & neurosurgery 030304 developmental biology |
| DOI: | 10.1101/2020.04.27.20079970 |
| Popis: | BackgroundMyelin plasticity has emerged as a novel mechanism by which the nervous system can change with experience, offering new potential for rehabilitation-induced recovery after neurotrauma. This first-in-human study investigated whether innovative, downhill locomotor rehabilitation promotes myelin plasticity in individuals with chronic, incomplete spinal cord injury (SCI).MethodsOf 20 individuals with SCI that enrolled, 4 passed the imaging screen and had myelin water imaging (MWI) before and after a 12-week (3 times/week) downhill locomotor treadmill training program (SCI+DH). One individual was excluded for imaging artifacts. Uninjured control participants (n=7) had two MWI sessions within the same day. Changes in myelin water fraction (MWF), a histopathologically-validated myelin biomarker, were analyzed in a priori motor learning and non-motor learning brain regions and the cervical spinal cord using statistical approaches appropriate for small sample sizes.ResultsWithin SCI+DH individuals, significantly more motor learning regions showed increased MWF than non-motor learning regions (pConclusionDownhill training increased MWF in brain regions specifically associated with motor learning and in the ventral spinal cord.Trial RegistrationClincialTrials.gov (NCT02498548, NCT02821845)FundingNational Institutes of Health [F31NS096921 (TDF), R21HD082808 (DMB)], Craig H. Neilsen Foundation [316282 (DMB)], Foundation for Physical Therapy Research [Promotion of Doctoral Studies Level II Scholarship (TDF)] |
| Databáze: | OpenAIRE |
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