Radiological and Histological Improvement of Oxalate Osteopathy After Combined Liver-Kidney Transplantation in Primary Hyperoxaluria Type 1
| Autor: | Jean Lambert Pasteels, Luc De Pauw, Charles Toussaint, Jean Quintin, Michel Gelin, Anne Vienne, Pierre-Alain Gevenois |
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| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
Adolescent Bone disease medicine.medical_treatment Liver transplantation Bone and Bones Primary hyperoxaluria Bone Density medicine Primary Hyperoxaluria Type I Humans Kidney transplantation Oxalates Serial Transplantation Hip Fractures business.industry Femur Head medicine.disease Kidney Transplantation Liver Transplantation Surgery Transplantation Bone Diseases Metabolic Nephrology Creatinine Hyperoxaluria Primary Shoulder Fractures Kidney Failure Chronic Female Hip Prosthesis Hemodialysis business |
| Zdroj: | American Journal of Kidney Diseases. 21:54-63 |
| ISSN: | 0272-6386 |
| DOI: | 10.1016/s0272-6386(12)80722-0 |
| Popis: | A 15-year-old patient with severe bone disease (with bilateral fractures of hips and shoulders) due to primary hyperoxaluria type 1 (PH1) was treated with combined liver-kidney transplantation after a 4-year hemodialysis period. Normalization of excessive oxalate synthesis brought in by the liver graft combined with the slow excretion of skeletal oxalate stores by the renal graft led to progressive improvement of clinical, radiological, and histological evidence of oxalate osteopathy. This allowed bilateral hip replacement 3 years after transplantation, which led to complete physical rehabilitation of the crippled patient. Combined liver-kidney transplantation constitutes the treatment of choice for end-stage renal failure due to PH1, even in the face of severe oxalate bone disease. |
| Databáze: | OpenAIRE |
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