Effects of active immunisation with myelin basic protein and myelin-derived altered peptide ligand on pain hypersensitivity and neuroinflammation
| Autor: | Preet G.S. Makker, Justin G. Lees, Vasso Apostolopoulos, Samuel S. Duffy, Gila Moalem-Taylor, Brett Fivelman, Chamini J. Perera |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Pain Threshold Time Factors T-Lymphocytes Immunology Freund's Adjuvant Pain Ligands Lymphocyte Activation Myelin immune system diseases Threshold of pain medicine Hypersensitivity Immunology and Allergy Animals Humans Neuroinflammation Pain Measurement biology Microglia business.industry Multiple sclerosis Experimental autoimmune encephalomyelitis Vaccination Histocompatibility Antigens Class II Myelin Basic Protein Myelitis medicine.disease Peptide Fragments Myelin basic protein Rats Disease Models Animal medicine.anatomical_structure Neurology Spinal Cord Rats Inbred Lew Neuropathic pain biology.protein Exploratory Behavior Neurology (clinical) business |
| Zdroj: | Journal of neuroimmunology. 286 |
| ISSN: | 1872-8421 |
| Popis: | Neuropathic pain is a debilitating condition in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE). Specific myelin basic protein (MBP) peptides are encephalitogenic, and myelin-derived altered peptide ligands (APLs) are capable of preventing and ameliorating EAE. We investigated the effects of active immunisation with a weakly encephalitogenic epitope of MBP (MBP87-99) and its mutant APL (Cyclo-87-99[A(91),A(96)]MBP87-99) on pain hypersensitivity and neuroinflammation in Lewis rats. MBP-treated rats exhibited significant mechanical and thermal pain hypersensitivity associated with infiltration of T cells, MHC class II expression and microglia activation in the spinal cord, without developing clinical signs of paralysis. Co-immunisation with APL significantly decreased pain hypersensitivity and neuroinflammation emphasising the important role of neuroimmune crosstalk in neuropathic pain. |
| Databáze: | OpenAIRE |
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