Prevalence and long-term clinical significance of intracranial atherosclerosis after ischaemic stroke or transient ischaemic attack: a cohort study
| Autor: | Sverre Rosenbaum, Annemette Abild, Hanne Christensen, Anders F. Christensen, Jens Kellberg Nielsen, Christine Krarup Hansen, Inger Havsteen, Christian Ovesen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Neurology medicine.medical_treatment Lumen (anatomy) STROKE MEDICINE Internal medicine medicine cardiovascular diseases Prospective cohort study Stroke medicine.diagnostic_test business.industry Arterial stenosis Research General Medicine Thrombolysis medicine.disease Surgery Angiography Cardiology business Cohort study |
| Zdroj: | BMJ Open |
| ISSN: | 2044-6055 |
| Popis: | Objectives We investigated the prevalence and long-term risk associated with intracranial atherosclerosis identified during routine evaluation. Design This study presents data from a prospective cohort of patients admitted to our stroke unit for thrombolysis evaluation. Setting and participants We included 652 with a final diagnosis of ischaemic stroke or transient ischaemic attack (TIA) from April 2009 to December 2011. All patients were acutely evaluated with cerebral CT and CT angiography (CTA). Acute radiological examinations were screened for intracranial arterial stenosis (IAS) or intracranial arterial calcifications (IAC). Intracranial stenosis was grouped into 30–50%, 50–70% and >70% lumen reduction. The extent of IAC was graded as number of vessels affected. Primary and secondary outcome measure Patients were followed until July 2013. Recurrence of an ischaemic event (stroke, ischaemic heart disease (IHD) and TIA) was documented through the national chart system. Poor outcome was defined as death or recurrence of ischaemic event. Results 101 (15.5%) patients showed IAS (70: 30–50%, 29: 50–70% and 16: >70%). Two-hundred and fifteen (33%) patients had no IAC, 339 (52%) in 1–2 vessels and 102 (16%) in >2 vessels. During follow-up, 53 strokes, 20 TIA and 14 IHD occurred, and 95 patients died. The risk of poor outcome was significantly different among different extents of IAS as well as IAC (log-rank test p |
| Databáze: | OpenAIRE |
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