Misclassification of exposure is high when interview data on drug use are used as a proxy measure of chronic drug use during follow-up
| Autor: | Hubert G. M. Leufkens, Annette B. Beiderbeck, Miriam C. J. M. Sturkenboom, Bruno H. Ch. Stricker, Jan W. Coebergh |
|---|---|
| Přispěvatelé: | Epidemiology |
| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Epidemiology Pharmacy Drug Prescriptions Drug Administration Schedule Medical Records Pharmacy records Rotterdam Study Bias Neoplasms Pharmacovigilance medicine Humans Information bias music Aged Netherlands Aged 80 and over Pharmacies Dose-Response Relationship Drug business.industry Pharmacoepidemiology music.record_label Calcium Channel Blockers Surgery Emergency medicine Cohort Observational study Female business Epidemiologic Methods |
| Zdroj: | Journal of Clinical Epidemiology, 57, 973-977. Elsevier Inc. |
| ISSN: | 0895-4356 |
| Popis: | Background and objective In many observational studies, the association between drugs and disease is analyzed with information from a baseline interview. We investigated the magnitude and direction of exposure misclassification by comparing interview data at baseline with prospectively gathered pharmacy data. Methods The study population for this study consisted of a cohort of 2,487 participants aged 71 years or older from the Rotterdam Study. Data on drug use were gathered at the baseline interview and through pharmacies during the follow-up period between January 1, 1991, and January 1, 1999. We assessed the sensitivity, specificity, and positive and negative predictive value of interview data as proxy measures of chronic use of calcium channel blockers (CCB) in comparison with longitudinal medication records from the pharmacy. Results Only 3 of the 206 subjects (1.5%) who reported use at baseline did not use CCBs during follow-up. Of the 2,281 persons who reported no use of CCBs at baseline, however, 354 actually used CCBs during follow-up (15.5%). The difference between interview data and pharmacy records corresponded to a misclassification bias of 0.73 (95%CI: 0.52-1.02). Conclusion Misclassification of exposure was high when interview data were used as a proxy measure of chronic use during follow-up. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect