Cathepsin Z as a novel potential biomarker for osteoporosis
| Autor: | Sandra Hamill, Dong Liu Barraclough, Sobhan Vinjamuri, Lakshminarayan Ranganath, Roger Barraclough, Ayed A. Dera |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Osteoporosis Gene Expression lcsh:Medicine Peripheral blood mononuclear cell Article Bone remodeling Fractures Bone 03 medical and health sciences 0302 clinical medicine Bone Density Internal medicine medicine Humans RNA Messenger lcsh:Science Aged Femoral neck Inflammation Bone mineral Cathepsin Multidisciplinary business.industry lcsh:R Cathepsin Z Diagnostic markers Middle Aged Prognosis medicine.disease Osteopenia Bone Diseases Metabolic 030104 developmental biology medicine.anatomical_structure Endocrinology ROC Curve Leukocytes Mononuclear Female lcsh:Q business Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Osteoporosis, one of the most prevalent chronic ageing-related bone diseases, often goes undetected until the first fragility fracture occurs, causing patient suffering and cost to health/social care services. Osteoporosis arises from imbalanced activity of osteoclasts and osteoblasts. Since these cell lineages produce the protease, cathepsin Z, the aim of this study was to investigate whether altered cathepsin Z mRNA levels are associated with osteoporosis in clinical samples. Cathepsin Z mRNA in human peripheral blood mononuclear cells was significantly differentially-expressed among non-osteoporotic controls, osteopenia and osteoporosis patients (p P = 0.0016). Cathepsin Z mRNA level strongly correlated with low bone mineral density (BMD) (g/cm2), lumbar spine L2-L4 and femoral neck (T-scores) (P = 0.0149, 0.0002 and 0.0139, respectively). Importantly, cathepsin Z mRNA was significantly associated with fragility fracture in osteoporosis patients (P = 0.0018). The levels of cathepsin Z mRNA were not significantly higher in patients with chronic inflammatory disorders in these two groups compared to those without (P = 0.774 and 0.666, respectively). ROC analysis showed that cathepsin Z mRNA has strong diagnostic value for osteoporosis and osteoporotic fracture. The results show for the first time that cathepsin Z could be a future diagnostic biomarker for osteoporosis including female osteoporosis patients over the age of 50 years. |
| Databáze: | OpenAIRE |
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