Neutralizing antibody-independent containment of immunodeficiency virus challenges by DNA priming and recombinant pox virus booster immunizations
| Autor: | M. L. Kalish, Kelledy Manson, Michael S. Wyand, S. L. Lydy, James G. Herndon, David C. Montefiori, Harriet L. Robinson, Harold M. McClure, Shan Lu, R P Johnson, Tahir A. Rizvi, M A Candido, J. D. Lifson, Dennis Panicali, Rhona L. Glickman, Shiu Lok Hu, Gail P. Mazzara |
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| Rok vydání: | 1999 |
| Předmět: |
Injections
Intradermal viruses Heterologous Priming (immunology) Virulence Antibodies Viral General Biochemistry Genetics and Molecular Biology law.invention Neutralization Tests law Vaccines DNA Animals Primary isolate Neutralizing antibody Fowlpox virus biology Vaccination Viral Vaccines General Medicine Virology Lentivirus Infections biology.protein Recombinant DNA Macaca RNA Viral Antibody T-Lymphocytes Cytotoxic |
| Zdroj: | Nature Medicine. 5:526-534 |
| ISSN: | 1546-170X 1078-8956 |
| DOI: | 10.1038/8406 |
| Popis: | Eight different protocols were compared for their ability to raise protection against immunodeficiency virus challenges in rhesus macaques. The most promising containment of challenge infections was achieved by intradermal DNA priming followed by recombinant fowl pox virus booster immunizations. This containment did not require neutralizing antibody and was active for a series of challenges ending with a highly virulent virus with a primary isolate envelope heterologous to the immunizing strain. |
| Databáze: | OpenAIRE |
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