Oxamyl dipeptide caspase inhibitors developed for the treatment of stroke

Autor:	Robert Smidt, Silvio Roggo, Julia Herrmann, Edward D. Robinson, Kathy G. Jahangiri, Teresa Aja, Kip Nalley, Thomas L. Deckwerth, Giorgio Rovelli, Kevin J. Tomaselli, Joe C. Wu, Bastian Hengerer, Steven P. Meduna, André Sauter, Jose-Luis Diaz, Joerg Kallen, Albert Schmitz, Donald S. Karanewsky, Brett R. Ullman, Steven D. Linton, Christoph Wiessner, Robert J. Ternansky, Peter R. Allegrini, Robert O. Sayers
Rok vydání:	2004
Předmět:	Peptidomimetic Stereochemistry Clinical Biochemistry Pharmaceutical Science Oxamyl Apoptosis Peptide Biochemistry Cell Line Inhibitory Concentration 50 Structure-Activity Relationship chemistry.chemical_compound Drug Discovery Humans Structure–activity relationship Molecular Biology Caspase chemistry.chemical_classification Dipeptide biology Organic Chemistry Neurodegenerative Diseases Dipeptides Caspase Inhibitors In vitro Stroke Kinetics chemistry Enzyme inhibitor biology.protein Molecular Medicine Carbamates
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 14:2685-2691
ISSN:	0960-894X
Popis:	Structural modifications were made to a previously described acyl dipeptide caspase inhibitor, leading to the oxamyl dipeptide series. Subsequent SAR studies directed toward the warhead, P2, and P4 regions of this novel peptidomimetic are described herein.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fb680f6d4dacf778afb32ec56f318e3 https://doi.org/10.1016/j.bmcl.2003.12.106 Zobrazit plný text záznamu Full Text from ScienceDirect