Dieting decreases plasma tryptophan and increases the prolactin response to d-fenfluramine in women but not men
| Autor: | A. E. S. Walsh, M. Franklin, A.D. Oldman, Christopher G. Fairburn, Phil J. Cowen |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Serotonin Diet Reducing Fenfluramine Calorie restriction chemistry.chemical_compound Internal medicine medicine Humans Neurotransmitter 5-HT receptor Analysis of Variance Sex Characteristics Tryptophan Brain Reproducibility of Results Prolactin Psychiatry and Mental health Clinical Psychology Endocrinology chemistry Female medicine.symptom Psychology Dieting medicine.drug |
| Popis: | We studied the effect of 3 weeks of moderate calorie restriction on 5-HT-mediated prolactin (PRL) release in healthy volunteers using the 5-HT-releasing agent d-fenfluramine. In women, dieting significantly lowered plasma total and free tryptophan (TRP) and increased the PRL response to d-fenfluramine. None of these measures were altered in men who dieted. These findings add to the data indicating that dieting alters brain 5-HT function in women, perhaps as a consequence of reducing the availability of plasma TRP. |
| Databáze: | OpenAIRE |
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