Sexual dimorphism in cognitive disorders in a murine model of neuropathic pain

Autor: Keebum Park, Hyoungsub Lim, Soonmi Won, Sung Joong Lee
Rok vydání: 2020
Předmět:
Male
Neurology
Morris water navigation task
Anxiety
Bioinformatics
lcsh:RC346-429
Open field
Mice
Behavioral Neuroscience
0302 clinical medicine
Pain Measurement
Sex Characteristics
0303 health sciences
Depression
Cognitive deficits
Chronic pain
Cognition
General Medicine
Hindlimb Suspension
Neuropathic pain
Female
Chronic Pain
medicine.symptom
Pain Threshold
medicine.medical_specialty
Cognitive Neuroscience
Motor Activity
Chronic neuropathic pain
Sexual dimorphism
03 medical and health sciences
medicine
Animals
Nociception assay
Maze Learning
lcsh:Neurology. Diseases of the nervous system
Spinal Cord Injuries
Swimming
Biological Psychiatry
030304 developmental biology
business.industry
Research
Recognition
Psychology
medicine.disease
Mice
Inbred C57BL
Disease Models
Animal
Neuralgia
Cognition Disorders
business
030217 neurology & neurosurgery
Zdroj: Behavioral and Brain Functions : BBF
Behavioral and Brain Functions, Vol 16, Iss 1, Pp 1-10 (2020)
ISSN: 1744-9081
DOI: 10.1186/s12993-019-0164-0
Popis: BackgroundA sex-difference in susceptibility to chronic pain is well-known. Although recent studies have begun to reveal the sex-dependent mechanisms of nerve injury-induced pain sensitization, sex differences in the affective and cognitive brain dysfunctions associated with chronic pain have not been investigated. Therefore, we tested whether chronic pain leads to affective and cognitive disorders in a mouse neuropathic pain model and whether those disorders are sexually dimorphic.MethodsChronic neuropathic pain was induced in male and female mice by L5 spinal nerve transection (SNT) injury. Pain sensitivity was measured with the von Frey test. Affective behaviors such as depression and anxiety were assessed by the forced swim, tail suspension, and open field tests. Cognitive brain function was assessed with the Morris water maze and the novel object location and novel object recognition tests.ResultsMechanical allodynia was induced and maintained for up to 8 weeks after SNT in both male and female mice. Depressive- and anxiety-like behaviors were observed 8 weeks post-SNT injury regardless of sex. Chronic pain-induced cognitive deficits measured with the Morris water maze and novel object location test were seen only in male mice, not in female mice.ConclusionsChronic neuropathic pain is accompanied by anxiety- and depressive-like behaviors in a mouse model regardless of sex, and male mice are more vulnerable than female mice to chronic pain-associated cognitive deficits.
Databáze: OpenAIRE
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