Cytochalasin D suppresses beta-adrenergic induced protein discharge without inhibiting membrane fusion
| Autor: | A. M. Chambaut-Guérin, L. Ovtracht, C. Huleux-Maurs, S. Busson-Mabillot, Bernard Rossignol |
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| Rok vydání: | 1985 |
| Předmět: |
Male
medicine.medical_specialty Cytochalasin D Stimulation Vacuole In Vitro Techniques Biology Cytoplasmic Granules Microfilament Membrane Fusion chemistry.chemical_compound Isoprenaline Internal medicine medicine Animals Parotid Gland Cytochalasin Secretion Isoproterenol Proteins Lipid bilayer fusion Rats Inbred Strains Cell Biology General Medicine Cytochalasins Rats Cell biology Endocrinology chemistry medicine.drug |
| Zdroj: | Biology of the Cell. 53:195-198 |
| ISSN: | 0248-4900 |
| Popis: | Biochemical studies have shown that low doses of Cytochalasin D (CD) inhibit protein discharge evoked by isoproterenol, a beta-adrenergic inducer, in isolated lobules of Rat parotid gland. Ultrastructural and radioautographic studies reported here indicate that, when lobules are treated by CD before isoproterenol stimulation, the connection of secretory granules with the acinar lumen is indeed prevented, but fusion of membrane granules evoked by isoproterenol still occurs. This fusion takes place with vacuoles induced by CD and possibly with other granules. |
| Databáze: | OpenAIRE |
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