Intra-individual variation of plasma trimethylamine-N-oxide (TMAO), betaine and choline over 1 year
Autor: | Theron Johnson, Daniel Müller, Disorn Sookthai, Arnold von Eckardstein, Rudolf Kaaks, Verena Katzke, Sabine Rohrmann, Tilman Kühn |
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Přispěvatelé: | University of Zurich, Kühn, Tilman |
Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
Male medicine.medical_specialty Time Factors Metabolite Clinical Biochemistry Population Trimethylamine N-oxide 610 Medicine & health 030204 cardiovascular system & hematology 1308 Clinical Biochemistry 2704 Biochemistry (medical) Mass Spectrometry Choline 03 medical and health sciences chemistry.chemical_compound Methylamines 0302 clinical medicine Betaine Internal medicine medicine Humans Prospective cohort study education 10038 Institute of Clinical Chemistry Aged Aged 80 and over Creatinine education.field_of_study Biochemistry (medical) General Medicine 10060 Epidemiology Biostatistics and Prevention Institute (EBPI) Middle Aged 030104 developmental biology Endocrinology chemistry Biochemistry Female Lipoprotein Chromatography Liquid |
Zdroj: | Clinical chemistry and laboratory medicine. 55(2) |
ISSN: | 1437-4331 |
Popis: | Background: Circulating trimethylamine-N-oxide (TMAO) has been implicated in the development of cardiovascular and chronic kidney diseases (CKD). However, while higher TMAO levels have been associated with increased risks of cardiovascular or renal events in first prospective studies, it remained unclear how much plasma TMAO concentrations vary over time. Methods: We measured fasting plasma levels of TMAO and two of its precursors, betaine and choline by LC-MS, in two samples of 100 participants of the European Investigation into Cancer and Nutrition (EPIC)-Heidelberg study (age range: 47–80 years, 50% female) that were collected 1 year apart, and assessed their intra-individual variation by Spearman’s correlation coefficients (ρ). Results: Correlations of metabolite concentrations over 1 year were at ρ=0.29 (p=0.003) for TMAO, ρ=0.81 (p Conclusions: In contrast to fasting plasma concentrations of betaine and choline, concentrations of TMAO were more strongly affected by intra-individual variation over 1 year in adults from the general population. The modest correlation of TMAO levels over time should be considered when interpreting associations between TMAO levels and disease endpoints. |
Databáze: | OpenAIRE |
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