Histopathological characteristics of metastasizing squamous cell carcinoma of the skin and lips
| Autor: | C J Peutz-Kootstra, M. R. T. M. Thissen, P. J. F. Quaedvlieg, G. Epping, G. A. Krekels, David Creytens, F H M Nieman |
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| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
squamous cell carcinoma
Male Pathology medicine.medical_specialty Histology Skin Neoplasms Perineural invasion Pathology and Forensic Medicine Metastasis Skin Squamous Cell Carcinoma medicine metastasis Humans Neoplasm Invasiveness Grading (tumors) Aged business.industry General Medicine Original Articles medicine.disease Desmoplasia stomatognathic diseases Epidermoid carcinoma Head and Neck Neoplasms Lymphatic Metastasis Lip Neoplasms histopathology Carcinoma Squamous Cell Histopathology Female Skin cancer medicine.symptom business |
| Zdroj: | Histopathology |
| ISSN: | 1365-2559 0309-0167 |
| Popis: | Quaedvlieg P J F, Creytens D H K V, Epping G G, Peutz-Kootstra C J, Nieman F H M, Thissen M R T M & Krekels G A (2006) Histopathology 49, 256–264 Histopathological characteristics of metastasizing squamous cell carcinoma of the skin and lips Aims The reported incidence of metastasis from squamous cell carcinoma (SCC) of the skin and lip varies between 0.5% and 16%. Clinical and histopathological criteria have been proposed to identify tumours that may have an increased risk of metastasis. The aim of this study was to define such high-risk tumours, especially since the incidence of SCC of the skin is increasing. Methods and results Histopathological features of metastasized skin and lip tumours and a matched group of non-metastasizing tumours were reassessed. Characteristics studied were: tumour width, excision margins, histological subtype, Clark level, Breslow depth, tumour differentiation, inflammation, perineural and angio-invasive growth, ulceration and desmoplasia. Data were statistically analysed separately for skin and labial lesions. Desmoplasia, Clark level, Breslow depth, maximum diameter, angio-invasion, grading, perineural invasion, plasma cells and eosinophilic inflammatory response proved to be statistically significantly related to metastasis of skin tumours. Breslow depth, plasma cells and grading appeared to be statistically significantly related to metastasis of SCC of the lips. Conclusions A typical metastatic SCC showed: a tumour width of at least 15 mm, a vertical tumour thickness (= Breslow) of at least 2 mm, less differentiation, presence of desmoplasia and an inflammatory response with eosinophils and plasma cells. |
| Databáze: | OpenAIRE |
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