ChT1, an Ig superfamily molecule required for T cell differentiation
| Autor: | Katevuo K, Ba, Imhof, Boyd R, Ann Chidgey, Bean A, Dunon D, Tw, Göbel, Vainio O |
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| Rok vydání: | 1999 |
| Předmět: |
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Complementary Lymphoid Tissue T-Lymphocytes Immunology Molecular Sequence Data T-Lymphocytes/ cytology/ immunology Immunoglobulins Chick Embryo Thymus Gland ddc:616.07 CD5 Antigens Antigens CD5/genetics/ immunology Organ Culture Techniques Thymus Gland/cytology/ immunology/surgery Immunology and Allergy Animals Antigens Surface/genetics Tissue Distribution Amino Acid Sequence Membrane Proteins/genetics Cloning Molecular Lymphoid Tissue/embryology/immunology Bone Marrow Transplantation Base Sequence Sequence Homology Amino Acid Hematopoietic Stem Cells/immunology Membrane Proteins DNA Complementary/genetics Cell Differentiation Sequence Analysis DNA Hematopoietic Stem Cells Proto-Oncogene Proteins c-kit Immunoglobulins/genetics/ immunology Antigens Surface Proto-Oncogene Proteins c-kit/isolation & purification Chickens |
| Zdroj: | Monash University Europe PubMed Central Journal of Immunology, Vol. 162, No 10 (1999) pp. 5685-5694 |
| ISSN: | 0022-1767 |
| Popis: | The thymus is colonized by circulating progenitor cells that differentiate into mature T cells under the influence of the thymic microenvironment. We report here the cloning and function of the avian thymocyte Ag ChT1, a member of the Ig superfamily with one V-like and one C2-like domain. ChT1-positive embryonic bone marrow cells coexpressing c-kit give rise to mature T cells upon intrathymic cell transfer. ChT1-specific Ab inhibits T cell differentiation in embryonic thymic organ cultures and in thymocyte precursor cocultures on stromal cells. Thus, we provide clear evidence that ChT1 is a novel Ag on early T cell progenitors that plays an important role in the early stages of T cell development. |
| Databáze: | OpenAIRE |
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