Human papillomavirus type 16 variants in cervical intraepithelial neoplasia and invasive carcinoma in San Luis Potosí City, Mexico
| Autor: | Mireya Sánchez-Garza, Marco A Pineda, Rubén López-Revilla, Lina Riego, Julio Ortiz-Valdez |
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| Jazyk: | angličtina |
| Předmět: |
Gynecology
Cancer Research Invasive cervical cancer medicine.medical_specialty Invasive carcinoma business.industry Epidemiology Cervical intraepithelial neoplasia medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens lcsh:RC254-282 lcsh:Infectious and parasitic diseases Infectious Diseases Oncology medicine lcsh:RC109-216 Human papillomavirus business Research Article |
| Zdroj: | Infectious Agents and Cancer Infectious Agents and Cancer, Vol 4, Iss 1, p 3 (2009) |
| ISSN: | 1750-9378 |
| DOI: | 10.1186/1750-9378-4-3 |
| Popis: | Background In San Luis Potosí City cervical infection by human papillomavirus type 16 (HPV16) associated to dysplastic lesions is more prevalent in younger women. In this work HPV16 subtypes and variants associated to low-grade intraepithelial lesions (LSIL), high-grade intraepithelial lesions (HSIL) and invasive cervical cancer (ICC) of 38 women residing in San Luis Potosí City were identified by comparing their E6 open reading frame sequences. Results Three European (E) variants (E-P, n = 27; E-T350G, n = 7; E-C188G, n = 2) and one AA-a variant (n = 2) were identified among the 38 HPV16 sequences analyzed. E-P variant sequences contained 23 single nucleotide changes, two of which (A334G, A404T) had not been described before and allowed the phylogenetic separation from the other variants. E-P A334G sequences were the most prevalent (22 cases, 57.9%), followed by the E-P Ref prototype (8 cases, 21.1%) and E-P A404T (1 case, 2.6%) sequences. The HSIL + ICC fraction was 0.21 for the E-P A334G variants and 0.00 for the E-P Ref variants. Conclusion We conclude that in the women included in this study the HPV16 E subtype is 19 times more frequent than the AA subtype; that the circulating E variants are E-P (71.1%) > E-T350G (18.4%) > E-C188G (5.3%); that 71.0% of the E-P sequences carry the A334G single nucleotide change and appear to correspond to a HPV16 variant characteristic of San Luis Potosi City more oncogenic than the E-P Ref prototype. |
| Databáze: | OpenAIRE |
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