Strategies to Attenuate Myocardial Infarction and No-Reflow Through Preservation of Vascular Integrity by Pigment Epithelium-Derived Factor
| Autor: | Zhiwei Liu, Teng Sun, Xiaoyu Quan, Jiajun Pan, Zhongming Zhang, Hao Zhang, Tengteng Wei, Meng Wang, Xiucheng Liu, Zhimin Li, Hongyan Dong |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Male
Poor prognosis Pathology medicine.medical_specialty business.industry Myocardial Infarction medicine.disease Epithelium Rats medicine.anatomical_structure PEDF cardiovascular system Genetics medicine Animals Molecular Medicine Nerve Growth Factors cardiovascular diseases Myocardial infarction PIGMENT EPITHELIUM-DERIVED FACTOR Eye Proteins business Molecular Biology Value (mathematics) Serpins |
| Zdroj: | Human Gene Therapy. 33:330-345 |
| ISSN: | 1557-7422 1043-0342 |
| DOI: | 10.1089/hum.2021.068 |
| Popis: | The phenomenon of no-reflow seriously limits the therapeutic value of coronary recanalization and leads to poor prognosis. Recent studies have demonstrated the potential role of pigment epithelium-derived factor (PEDF) in stabilizing endothelial cell junction, reducing vascular permeability and maintaining a quiescent vasculature. In this study, intramyocardial gene delivery was performed 5 days before the acute myocardial infarction/recanalization experiment in male rats. Positron emission tomography perfusion imaging with |
| Databáze: | OpenAIRE |
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