MAdCAM-1 dependent colonization of developing lymph nodes involves a unique subset of CD4+CD3- hematolymphoid cells
| Autor: | Reina E. Mebius, Inge L. Schadee-Eestermans, Irving L. Weissman |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
CD4-Positive T-Lymphocytes
biology Follicular dendritic cells CD3 Complex Lymphocyte High endothelial venules Receptors Lymphocyte Homing Immunoglobulins hemic and immune systems General Medicine Hematopoietic Stem Cells Gut-specific homing Cell biology medicine.anatomical_structure Lymphatic system Mucoproteins Cell Movement Immunology medicine Addressin biology.protein Lymph node stromal cell Animals Lymph Nodes Lymph node |
| Zdroj: | Cell adhesion and communication. 6(2-3) |
| ISSN: | 1061-5385 |
| Popis: | During fetal lymph node organogenesis in mice, lymph node postcapillary high endothelial venules briefly express the Peyer's patch addressin MAdCAM-1. This allows initial seeding by two unusual lymphocyte populations selectively expressing the Peyer's patch homing receptor integrin alpha4beta 7: CD4+CD3- oligolineage progenitors and TCR gammadelta+ T cells. It was found that the CD4+CD3- cells are lineage-restricted progenitors that express surface lymphotoxin-beta (LTbeta) and the chemokine receptor BLR1. They can differentiate into natural killer cells, dendritic antigen-presenting cells, and follicular cells of unknown outcome, but these cells do not become T or B lymphocytes. In addition to LN, CD4+CD3- cells can also be found in fetal spleen starting at 13.5 dpc, while absent from fetal liver. In view of the necessity of lymphotoxin in lymphoid organ development, it is thought that the novel subset of CD4+CD3- LTbeta+ fetal cells is instrumental in the development of lymphoid tissue architecture. |
| Databáze: | OpenAIRE |
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