Plasma phospholipase, γ-CEHC and antioxidant capacity in fibromyalgia
| Autor: | Valeria Ruggiero, Luigi Atzori, Benedetta Era, Antonella Fais, Enrico Cacace |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
0301 basic medicine medicine.medical_specialty Pathology Fibromyalgia Enzyme-Linked Immunosorbent Assay Phospholipase Severity of Illness Index Antioxidants Phosphatidylcholine-Sterol O-Acyltransferase 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Rheumatology Disease severity Plasma enzyme Surveys and Questionnaires Internal medicine medicine Humans Chromans Phospholipases A2 Secretory 030203 arthritis & rheumatology Platelet-activating factor business.industry Middle Aged medicine.disease Antioxidant capacity 030104 developmental biology Endocrinology chemistry Case-Control Studies 1-Alkyl-2-acetylglycerophosphocholine Esterase Quality of Life Female Functional status Propionates business Biomarkers |
| Zdroj: | International Journal of Rheumatic Diseases. 20:550-554 |
| ISSN: | 1756-1841 |
| Popis: | Objective Recent studies have suggested a possible role of high levels of plasma lysophosphocholines (lysoPCs) in fibromyalgia syndrome (FMS). The aim of this study was to evaluate the content of plasma phospholipases (e.g., Platelet Activating Factor Acetyl Hydrolase [PAF-AH], secretory Phospholipase A2 [sPLA2], Total Antioxidant Capacity [TAOC] and 2,7,8-trimethyl-2-(2-carboxyethyl)-6-hydroxy chroman [γ-CEHC]) in FMS patients and their association with clinical status and quality of life. Methods Thirty-six females meeting the 2011 American College of Rheumatology criteria for the classification of FMS and thirty-four healthy females were enrolled for the study. Plasma enzyme levels were quantified using commercial enzyme-linked-immunosorbent-assay (ELISA). In order to assess the disease severity and the functional status of patients, the Fibromyalgia Impact Questionnarie (FIQ) was used. Results Higher levels of sPLA2 and lower PAF-AH and γ-CEHC were observed in the plasma of FMS patients compared to the controls. A decrease in PAF-AH and TAOC levels were found in severe FMS (S-FMS) compared to mild/slight (MS-FMS) forms. Conclusion The results of the study indicate a possible involvement of phospholipases and γ-CEHC in fibromyalgia syndrome. |
| Databáze: | OpenAIRE |
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