Are acetowhite lesions of the cervix correlated to the presence of Epstein-Barr virus DNA?

Autor: Monica Stenglein, Ewa Voog, Gun-Britt Löwhagen, Anne Ricksten, Annika Ternesten, Fredrik Jonassen, Walter Ryd
Rok vydání: 1997
Předmět:
Adult
Herpesvirus 4
Human
Pathology
medicine.medical_specialty
Adolescent
Biopsy
Uterine Cervical Neoplasms
Cervix Uteri
Dermatology
medicine.disease_cause
Cervical intraepithelial neoplasia
Polymerase Chain Reaction
Herpesviridae
law.invention
Uterine Cervical Diseases
law
hemic and lymphatic diseases
Cytology
Humans
Medicine
Pharmacology (medical)
Papillomaviridae
Cervix
In Situ Hybridization
Polymerase chain reaction
Colposcopy
medicine.diagnostic_test
business.industry
Papillomavirus Infections
Public Health
Environmental and Occupational Health
virus diseases
Herpesviridae Infections
Middle Aged
Uterine Cervical Dysplasia
medicine.disease
female genital diseases and pregnancy complications
Koilocyte
Virus Latency
Tumor Virus Infections
Infectious Diseases
medicine.anatomical_structure
DNA
Viral
RNA
Viral
Female
business
Zdroj: International Journal of STD & AIDS. 8:432-436
ISSN: 1758-1052
0956-4624
DOI: 10.1258/0956462971920488
Popis: The purpose of this study was to investigate whether Epstein-Barr virus (EBV) is associated with acetowhite lesions of the portio cervix, demonstrating koilocytosis and/or cervical intraepithelial neoplasia (CIN) I-III. The study group comprised 37 women admitted to the Department of Gynaecology and Obstetrics, Sahlgrenska University Hospital, Go teborg because of pathological colposcopy or cytology of the portio cervix. Colposcopically, all exhibited acetowhite lesions of the portio cervix. Cells were sampled with a cytobrush for examination for EBV and human papillomavirus (HPV) DNA by polymerase chain reaction (PCR) and a biopsy was taken for histopathology. Biopsies from 5 patients positive for EBV by PCR in cervical cell samples were examined by an in situ hybridization technique for EBER (Epstein-Barr virus encoded RNA), RNAs expressed in latent EBV infection. The control group consisted of women attending the Department of Dermato-Venereology at the same hospital for STD check-up. These had a normal cytology and no signs of acetowhiteness of the portio cervix. In the study group, EBV DNA was found in 30% and HPV DNA in 51%. In the control group 57% exhibited EBV DNA and 23% HPV DNA. EBV was not found to be a predictive factor in the development of koilocytosis and/or CIN I-III. HPV was a predictive factor in acetowhite, koilocytotic lesions. No expression of EBER was found in the 5 biopsies examined by in situ hybridization.
Databáze: OpenAIRE
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