Erythema nodosum and the risk of tuberculosis in a high incidence setting
| Autor: | Jacob Simonsen, Karin Ladefoged, Anders Koch, Aase Bengaard Andersen, Hans Christian Florian Sørensen, Bolette Søborg, Karen Bjorn-Mortensen, Sascha Wilk Michelsen, Troels Lillebaek |
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| Přispěvatelé: | The Commission for Scientific Research in Greenland, Forskningspuljen, Sundhedspuljen |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty lcsh:Arctic medicine. Tropical medicine Health (social science) Tuberculosis lcsh:RC955-962 Epidemiology Greenland Interferon gamma release assay Review Article Mycobacterium tuberculosis Cohort Studies 030207 dermatology & venereal diseases 03 medical and health sciences Young Adult 0302 clinical medicine Erythema Nodosum Risk Factors Internal medicine medicine Humans Erythema nodosum mycobacterium tuberculosis interferon gamma release assay Tuberculosis Pulmonary biology Proportional hazards model business.industry Incidence (epidemiology) Incidence Public Health Environmental and Occupational Health General Medicine biology.organism_classification medicine.disease Causality 030228 respiratory system Immunology BCG Vaccine Female business BCG vaccine Interferon-gamma Release Tests Cohort study |
| Zdroj: | International Journal of Circumpolar Health International Journal of Circumpolar Health; Vol 75 (2016) Bjorn-Mortensen, K, Ladefoged, K, Simonsen, J, Michelsen, S W, Sørensen, H C F, Koch, A, Lillebaek, T, Andersen, A B & Soborg, B 2016, ' Erythema nodosum and the risk of tuberculosis in a high incidence setting ', International Journal of Circumpolar Health, vol. 75, 32666 . https://doi.org/10.3402/ijch.v75.32666 International Journal of Circumpolar Health, Vol 75, Iss 0, Pp 1-6 (2016) Bjorn-Mortensen, K, Ladefoged, K, Simonsen, J, Michelsen, S W, Sørensen, H C F, Koch, A, Lillebaek, T, Andersen, A B & Soborg, B 2016, ' Erythema nodosum and the risk of tuberculosis in a high incidence setting ', International Journal of Circumpolar Health, vol. 75, 32666, pp. 1-6 . https://doi.org/10.3402/ijch.v75.32666 |
| ISSN: | 2242-3982 1239-9736 1797-237X |
| DOI: | 10.3402/ijch.v75.32666 |
| Popis: | Objective . This study estimates the erythema nodosum (EN) incidence in a tuberculosis (TB) endemic setting and evaluates the likelihood of a subsequent TB diagnosis among individuals with Mycobacterium tuberculosis infection (MTI) with or without EN. Design . We estimated EN incidence rates (IRs) in East Greenland in 2010–2011 and conducted a cohort study following all individuals who tested positive for MTI from 1 January 2010 until 31 December 2012. A personal identifier allowed individual follow-up in the mandatory TB register. MTI was defined by a positive interferon-gamma release assay. TB incidence rate ratios (IRRs) among participants with or without EN were estimated with the Cox proportional hazard model. Results . We identified 38 EN cases corresponding to an IR of 500/100,000 inhabitants/year. All cases were among individuals with MTI. The EN IR was 11.79 (95% CI 5.73–24.27) times higher for BCG-unvaccinated compared with BCG-vaccinated individuals. The TB IRR was 25 (95% CI 11–60) within 1 month of EN compared to individuals without EN. Conclusion . This study documents a high EN incidence in a TB endemic region. EN occurred only in individuals with MTI, and predominantly among BCG-unvaccinated individuals. EN was significantly associated with a TB diagnosis within 1 month of diagnosis. Keywords: Erythema Nodosum; interferon gamma release assay; mycobacterium tuberculosis; Tuberculosis; Greenland (Published: 25 October 2016) Citation: Int J Circumpolar Health 2016, 75: 32666 - http://dx.doi.org/10.3402/ijch.v75.32666 |
| Databáze: | OpenAIRE |
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