Birth weight in pregnancies complicated by maternal heart disease
| Autor: | Margaret Simpson, Janet Brennand, Sophie Haynes, Philip J. Steer, Monique Sterrenburg, Aarthi R Mohan, Thomas R. Everett, Matthew Cauldwell, Catherine E G Head, Mark R. Johnson, Suzanne Wallace, Gemma Malin, Adam D Jakes, Gemma Ulivi |
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| Rok vydání: | 2018 |
| Předmět: |
Percentile
medicine.medical_specialty Heart disease Heart Diseases Birth weight Cardiomyopathy Gestational Age 030204 cardiovascular system & hematology Fetal Development 03 medical and health sciences 0302 clinical medicine Pregnancy medicine Birth Weight Humans 1102 Cardiorespiratory Medicine and Haematology Tetralogy of Fallot 030219 obstetrics & reproductive medicine business.industry Obstetrics Infant Newborn Gestational age medicine.disease Cardiovascular System & Hematology Infant Small for Gestational Age Gestation Female Cardiology and Cardiovascular Medicine business |
| Popis: | ObjectiveTo assess median and percentile birthweight distribution in women with various groups of heart disease relative to a contemporaneous comparison group.MethodsData on birth weight and gestational age were collected from 1321 pregnancies ≥24 weeks’ gestation in 1053 women with heart disease from seven UK maternity units. Women were assigned to one of 16 groups according to their cardiac lesion. In units where it was possible, data on two births, one delivering before and one after index cases, were collected, giving 2307 comparators. Birthweight percentiles (corrected for gestational age, sex and parity) were calculated using Aberdeen norms. We assessed the association of birth weight with cardiac lesion, maternal hypoxaemia (saturations Results1321 pregnancies in women with heart disease and 2307 comparators were studied. Almost all groups with heart disease had lower median and percentile birth weights than comparators, significantly in 10 groups, the biggest effect seen in women with Fontan circulation, pulmonary hypertension, prosthetic heart valves, systemic right ventricle, Marfan syndrome, repaired tetralogy of Fallot and cardiomyopathy (in that order). In 307 pregnancies, women took beta-blockers; median birth weight adjusted for maternal age, parity and the effect of the cardiac lesion was 3116.7 g (IQR 790.4) when beta-blockers were used and 3354.3 g (IQR 634.1) when they were not (pConclusionOur findings identify specific groups of women with heart disease at risk of having a small baby. |
| Databáze: | OpenAIRE |
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