Effects of lithium on an amphetamine animal model of bipolar disorder
| Autor: | Philippe Cappeliez, Elizabeth Moore |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
medicine.medical_specialty Bipolar Disorder Dextroamphetamine Lithium (medication) medicine.medical_treatment Lithium Motor Activity Locomotor activity Open field chemistry.chemical_compound Animal model Chlorides Reference Values Internal medicine medicine Animals Bipolar disorder Amphetamine Saline Biological Psychiatry Pharmacology business.industry Rats Inbred Strains medicine.disease Rats Substance Withdrawal Syndrome Disease Models Animal Endocrinology chemistry Anesthesia Lithium chloride Lithium Chloride business medicine.drug |
| Zdroj: | Progress in Neuro-Psychopharmacology and Biological Psychiatry. 14:347-358 |
| ISSN: | 0278-5846 |
| Popis: | 1. This study examines the effects of chronic lithium administration on changes induced by amphetamine administration and withdrawal on open field locomotor activity of rats, and considered as an animal model of behaviors displayed in bipolar disorders. 2. For 21 days, rats were administered either single daily intraperitoneal injections (IP) of 0.9% saline, 0.15 mEq/kg, or 1.5 mEq/kg lithium chloride (LiCl). From day 7 to day 16, half of the animals in each group consisting of 12 rats were administered twice daily IP injections of either 1.5 mg/kg d-amphetamine or 0.9% saline. From day 17 to 21, d-amphetamine was withdrawn. 3. Neither dose of LiCl significantly altered the increases in activity levels produced by amphetamine. The withdrawal of amphetamine lead to an immediate return to baseline activity levels which neither dose of LiCl significantly affected. 4. The absence of interactive effects suggests that the influence of lithium and amphetamine on activity are mediated by different neurotransmitter systems. |
| Databáze: | OpenAIRE |
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