Two new actions of sea nettle (Chrysaora quinquecirrha) nematocyst venom: studies on the mechanism of actions on complement activation and on the central nervous system
| Autor: | Abulkalam M. Shamsuddin, Takatoshi Ishikawa, Joseph W. Burnett, Ivana Vucenik, Florin Niculescu |
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| Rok vydání: | 2004 |
| Předmět: |
Jellyfish
Central nervous system Venom In Vitro Techniques Pharmacology Administration Cutaneous Toxicology Chrysaora quinquecirrha Lethal Dose 50 Cyprinodontiformes 03 medical and health sciences Cnidarian Venoms biology.animal medicine Animals Humans Killifish Nematocyst Complement Activation 030304 developmental biology 0303 health sciences biology 030302 biochemistry & molecular biology Brain Sea Nettle East Coast Anatomy biology.organism_classification Epithelium Complement system medicine.anatomical_structure Rabbits |
| Zdroj: | Toxicon. 44:895-899 |
| ISSN: | 0041-0101 |
| DOI: | 10.1016/j.toxicon.2004.08.017 |
| Popis: | Chrysaora quinquecirrha (sea nettle) nematocyst venom is lethal to rainbow killifish (Adina xenica) when injected intraperitoneally or topically applied to the exposed brain or denuded epithelium. The lethal activity is thermostable requiring 100 degrees C heat for inactivation. This paper reports here for the first time that the venom also activates the complement system with the subsequent formation of the C5b-9 terminal complement complex. The events are associated with both a strong chemoattractant release and the tissue damage. These are also, at least in part, responsible for the pathogenesis of some clinical signs and symptoms associated to the jellyfish stings. |
| Databáze: | OpenAIRE |
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