Towards Implementation of OMOP in a German University Hospital Consortium
| Autor: | Johannes Bernarding, Julian Laufer, H. W. Fritsch, Christian Maier, F. Berger, Christian Haverkamp, Tim Herrmann, Holger Storf, R. Bieber, Patric Vormstein, Martin Sedlmayr, G. Höning, Thomas Ganslandt, L. Lang, Hans-Ulrich Prokosch, Jürgen Schüttler, Petar Horki |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Knowledge management
020205 medical informatics Computer science Health Informatics Translational research 02 engineering and technology computer.software_genre Vocabulary Terminology German Hospitals University 03 medical and health sciences OHDSI 0302 clinical medicine Health Information Management Germany Surveys and Questionnaires Health care Outcome Assessment Health Care 0202 electrical engineering electronic engineering information engineering Humans 030212 general & internal medicine Cooperative Behavior data integration business.industry secondary use Health Plan Implementation language.human_language Computer Science Applications Data sharing General partnership Informatics language business computer Data integration Research Article OMOP |
| Zdroj: | Applied Clinical Informatics |
| ISSN: | 1869-0327 |
| Popis: | Background In 2015, the German Federal Ministry of Education and Research initiated a large data integration and data sharing research initiative to improve the reuse of data from patient care and translational research. The Observational Medical Outcomes Partnership (OMOP) common data model and the Observational Health Data Sciences and Informatics (OHDSI) tools could be used as a core element in this initiative for harmonizing the terminologies used as well as facilitating the federation of research analyses across institutions. Objective To realize an OMOP/OHDSI-based pilot implementation within a consortium of eight German university hospitals, evaluate the applicability to support data harmonization and sharing among them, and identify potential enhancement requirements. Methods The vocabularies and terminological mapping required for importing the fact data were prepared, and the process for importing the data from the source files was designed. For eight German university hospitals, a virtual machine preconfigured with the OMOP database and the OHDSI tools as well as the jobs to import the data and conduct the analysis was provided. Last, a federated/distributed query to test the approach was executed. Results While the mapping of ICD-10 German Modification succeeded with a rate of 98.8% of all terms for diagnoses, the procedures could not be mapped and hence an extension to the OMOP standard terminologies had to be made.Overall, the data of 3 million inpatients with approximately 26 million conditions, 21 million procedures, and 23 million observations have been imported.A federated query to identify a cohort of colorectal cancer patients was successfully executed and yielded 16,701 patient cases visualized in a Sunburst plot. Conclusion OMOP/OHDSI is a viable open source solution for data integration in a German research consortium. Once the terminology problems can be solved, researchers can build on an active community for further development. |
| Databáze: | OpenAIRE |
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