Unaltered neurocardiovascular reactions to mental stress after renal sympathetic denervation
| Autor: | Bengt Rundqvist, Jonas Multing, Mikael Elam, Sebastian Völz, Bert Andersson, Linda C Lundblad |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Sympathetic Nervous System Physiology Resistant hypertension Blood Pressure 030204 cardiovascular system & hematology Kidney 03 medical and health sciences 0302 clinical medicine Heart Rate Internal medicine Mental stress Heart rate Internal Medicine medicine Humans Arterial Pressure 030212 general & internal medicine Sympathectomy Aged Denervation business.industry Sympathetic nerve activity Blood Pressure Determination Sympathetic activity General Medicine Treatment Outcome Blood pressure Renal sympathetic denervation Hypertension Cardiology Female business Stress Psychological |
| Zdroj: | Clinical and Experimental Hypertension. 42:160-166 |
| ISSN: | 1525-6006 1064-1963 |
| DOI: | 10.1080/10641963.2019.1590387 |
| Popis: | Background: The impact of renal denervation (RDN) on muscle sympathetic nerve activity (MSNA) at rest remains controversial. Mental stress (MS) induces transient changes in sympathetic nerve activity, heart rate (HR) and blood pressure (BP). It is not known whether RDN modifies these changes.Purpose: The main objective was to assess the effect of RDN on MSNA and BP alterations during MS.Methods: In 14 patients (11 included in analysis) with resistant hypertension multi-unit MSNA, BP (Finometer ®) and HR were assessed at rest and during forced arithmetics at baseline and 6 months after RDN.Results: Systolic office BP decreased significantly 6 months after RDN (185 ± 29 vs.175 ± 33 mmHG; p = 0.04). No significant changes in MSNA at rest (68 ± 5 vs 73 ± 5 bursts/100hb; p = 0.43) were noted and no significant stress-induced change in group averaged sympathetic activity was found pre- (101 ± 24%; p = 0.9) or post-intervention (108 ± 26%; p = 0.37). Stress was associated with significant increases in mean arterial BP (p < 0.01) and HR (p < 0.01) at baseline, reactions which remained unaltered after intervention. We did not note any correlation between sympathetic nerve activity and BP changes after RDN.Conclusion: Thus, in our group of resistant hypertensives we find no support for the hypothesis that the BP-lowering effect of RDN depends on altered neurovascular responses to stress. |
| Databáze: | OpenAIRE |
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