Metabolite-selective hyperpolarized (13)C imaging using extended chemical shift displacement at 9.4T
| Autor: | Hansol Lee, Daniel M. Spielman, Joonsung Lee, Jae Mo Park, Donghyun Kim, Young Suk Choi, Seungwook Yang, Ho Taek Song, Eunhae Joe |
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| Rok vydání: | 2015 |
| Předmět: |
Magnetic Resonance Spectroscopy
Metabolite Biomedical Engineering Biophysics Mice Nude Field strength Kidney Imaging phantom Article 030218 nuclear medicine & medical imaging 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Nuclear magnetic resonance High spatial resolution Animals Radiology Nuclear Medicine and imaging Shift displacement Carbon Isotopes Mice Inbred BALB C Phantoms Imaging Metabolic imaging Hyperpolarized 13c chemistry Artifacts 030217 neurology & neurosurgery Excitation |
| Zdroj: | Magnetic resonance imaging. 34(4) |
| ISSN: | 1873-5894 |
| Popis: | Purpose To develop a technique for frequency-selective hyperpolarized 13C metabolic imaging in ultra-high field strength which exploits the broad spatial chemical shift displacement in providing spectral and spatial selectivity. Methods The spatial chemical shift displacement caused by the slice-selection gradient was utilized in acquiring metabolite-selective images. Interleaved images of different metabolites were acquired by reversing the polarity of the slice-selection gradient at every repetition time, while using a low-bandwidth radio-frequency excitation pulse to alternatingly shift the displaced excitation bands outside the imaging subject. Demonstration of this technique is presented using 1H phantom and in vivo mouse renal hyperpolarized 13C imaging experiments with conventional chemical shift imaging and fast low-angle shot sequences. Results From phantom and in vivo mouse studies, the spectral selectivity of the proposed method is readily demonstrated using results of chemical shift spectroscopic imaging, which displayed clearly delineated images of different metabolites. Imaging results using the proposed method without spectral encoding also showed effective separation while also providing high spatial resolution. Conclusion This method provides a way to acquire spectrally selective hyperpolarized 13C metabolic images in a simple implementation, and with potential ability to support combination with more elaborate readout methods for faster imaging. |
| Databáze: | OpenAIRE |
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