Can resveratrol treatment control the progression of induced periodontal disease? a systematic review and meta-analysis of preclinical studies
| Autor: | James Newton Bizetto Meira de Andrade, Amanda Melo Sant’Anna Araújo, Débora Ribeiro Orlando, Eric Francelino Andrade, Renato Ribeiro de Lima, Diana Vilela Azzi, Adalfredo Rocha Lobo-Junior, Luciano José Pereira |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty 2 3 5 4′-tetrahydroxystilbene-2-O-β-glucoside Polifenóis lcsh:TX341-641 Inflammation Oral Health Review Resveratrol 03 medical and health sciences chemistry.chemical_compound Gingivitis 2 3 5 4'-tetrahydroxystilbene-2-O-β-glucoside 0302 clinical medicine Periodontal disease In vivo Functional Food Internal medicine medicine Animals Periodontitis Dental alveolus Periodontal Diseases Doenças da Boca Nutrition and Dietetics business.industry Anti-Inflammatory Agents Non-Steroidal 030206 dentistry medicine.disease 030104 developmental biology Alimento funcional chemistry Meta-analysis Periodontite Saúde Oral medicine.symptom business Mouth Diseases lcsh:Nutrition. Foods and food supply Food Science |
| Zdroj: | Nutrients Repositório Institucional da UFLA Universidade Federal de Lavras (UFLA) instacron:UFLA Nutrients, Vol 11, Iss 5, p 953 (2019) |
| Popis: | Resveratrol is an anti-inflammatory compound found in several foods. Periodontal disease (PD) is associated to other systemic diseases, and inflammation may be responsible for the association. Consequently, controlling inflammation not only may benefit oral health but also may assist with the management of other chronic inflammatory conditions. We aimed to investigate the effects of resveratrol administration on PD control in preclinical studies. A systematic search was performed for scientific articles using both electronic databases and a manual search using combinations of the following keywords: “resveratrol” OR “3,5,4′-trihydroxystilbene” AND “periodontal disease” OR “periodontitis” OR “gingivitis”. Only in vivo original studies investigating resveratrol treatment on experimental animal models of PD were selected. A quality assessment of the studies was performed using the Animal Research Reporting In Vivo Experiment (ARRIVE) guidelines, and the risk of bias was assessed using the Syrcle tool. The search returned 570 articles, and 11 matched the inclusion criteria. A meta-analysis showed that resveratrol treatment attenuated alveolar bone loss (τ2 = 0.0041; 95% CI: −0.14; −0.04). The ARRIVE criteria reported a good quality of studies in general (mean score 28.5 ± 2.5). However, five Syrcle domains indicated a high risk of bias or did not present information clearly. We concluded that, in preclinical studies, resveratrol treatment prevented PD progression. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|