| Autor: |
Marian E. Melish, G Kurth, M Drummond, Robert T. Hall, B Pollock, M Brown, V Sutherland, Laurence B. Givner, JA Garcia Prats, Carol J. Baker, R Ramamurthy, L Hayen, D Hesketh, V Meade, MA Rench, Driscoll, S Pelke, Ushanalini Vasan, Daniel T. Casto |
| Rok vydání: |
1993 |
| Předmět: |
|
| Zdroj: |
International Journal of Gynecology & Obstetrics. 40:278-279 |
| ISSN: |
0020-7292 |
| DOI: |
10.1016/0020-7292(93)90897-6 |
| Popis: |
Background. Nosocomial infection is a major risk for premature infants with very low birth weights. One reason for their susceptibility to infection may be antibody deficiency, since there is little transfer of maternal IgG to the fetus before 32 weeks' gestation. Methods. We conducted a multicenter, double-blind study of neonates weighing 500 to 1750 g at birth. A total of 588 neonates were randomly assigned, with stratification for birth weight, to receive periodic intravenous infusions of either immune globulin (500 mg per kilogram of body weight per day) or a placebo. Mortality, morbidity, and nosocomial infection during the next 56 days were assessed. Results. The infusions were well tolerated; mild, reversible adverse reactions occurred in five infants in each group. There was a significant reduction in the risk of a first nosocomial infection in the recipients of immune globulin as compared with the placebo recipients (relative risk, 0.7; 95 percent confidence interval, 0.5 to 0.9). About ... |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
Plný text