| Autor: |
Elisabet Johansson, Jocelyn M. Biagini, Lisa J. Martin, Hua He, John W. Kroner, Cassandra Almasri, Veronica Velasquez, Maud Sonzogni, Stanley B. DeVore, Daniel Spagna, Brittany Grashel, Gurjit K. Khurana Hershey |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Ann Allergy Asthma Immunol |
| ISSN: |
1534-4436 |
| Popis: |
BACKGROUND: In addition to its involvement in both the innate and adaptive immune systems, vitamin D has also been found to affect keratinocyte function and proliferation, suggesting a possible role for vitamin D in cutaneous allergic sensitization. OBJECTIVE: To explore the role of circulating vitamin D levels in allergic sensitization. METHODS: Serum 25-hydroxyvitamin D (25(OH)D) levels were measured in a subset of children (N=323) enrolled in the Mechanisms of Progression from AD to Asthma in Children (MPAACH) cohort, a prospective early-life cohort of children with atopic dermatitis. Allergic sensitization was determined using skin prick testing, and FLG expression in keratinocytes was measured by quantitative PCR. Multiple Poisson regression was used to evaluate interaction effects between serum 25(OH)D levels and FLG expression with sensitization load as the outcome. RESULTS: Black participants had significantly lower mean levels of serum 25(OH)D compared with non-Black participants (29.3 vs. 32.9 ng/ml; p < 0.001). FLG expression and sensitization load were negatively correlated in non-Black participants with 25(OH)D levels < 27.2 ng/ml (Rho = −0.45; p=0.026). No association between FLG expression and sensitization load was found in Black participants or participants with 25(OH)D levels ≥ 27.2 ng/ml. Multiple Poisson regression models confirmed that 25(OH)D levels interact with FLG expression to affect sensitization load in non-Black participants. CONCLUSION: Despite lower vitamin D levels in Black participants, sensitization load was associated with non-lesional skin FLG expression in non-Black, but not Black, children with low vitamin D levels. Thus, a complex interplay of factors determines the impact of vitamin D on allergic sensitization. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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