Sunitinib-induced acute severe hypothyroidism in a case of metastatic gastrointestinal stromal tumor: A case report
| Autor: | Chhaya Roy, Kazi Sazzad Manir, Rahul Bhowmick, Debanti Banerjee |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Indoles endocrine system diseases Gastrointestinal Stromal Tumors sunitinib Levothyroxine Thyrotropin 010501 environmental sciences lcsh:RC254-282 01 natural sciences Gastroenterology 03 medical and health sciences Transient hypothyroidism 0302 clinical medicine Hypothyroidism Internal medicine medicine Humans Pyrroles Radiology Nuclear Medicine and imaging Stromal tumor Aged thyroxine 0105 earth and related environmental sciences Sunitinib business.industry General Medicine lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Thyroid abnormalities Severe hypothyroidism Oncology 030220 oncology & carcinogenesis Thyroid stimulating hormone level Thyroid function business medicine.drug |
| Zdroj: | Journal of Cancer Research and Therapeutics, Vol 14, Iss 10, Pp 818-819 (2018) |
| ISSN: | 0973-1482 |
| DOI: | 10.4103/0973-1482.199443 |
| Popis: | Thyroid abnormalities are found nearly 70% cases receiving sunitinib therapy. Mostly, patients suffer transient hypothyroidism rarely presents with overt acute symptoms requiring levothyroxine replacement. Onset is variable in published literature. We report a case of metastatic gastrointestinal stromal tumor receiving sunitinib with normal baseline thyroid function. The patient developed symptoms of acute severe hypothyroidism with high thyroid stimulating hormone level on the 4th week of therapy. The patient responded with oral levothyroxine. clinical and biochemical parameter resolved rapidly. Patient receiving sunitinib warns baseline and subsequent surveillance of thyroid function (both clinical and biochemical). This rare dreadful condition reverts promptly with thyroxine replacement. |
| Databáze: | OpenAIRE |
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