Genetic Modifiers and Phenotype of Duchenne Muscular Dystrophy: A Systematic Review and Meta-Analysis
| Autor: | Carlos Pascual-Morena, Iván Cavero-Redondo, Irene Sequí-Domínguez, Alicia Saz-Lara, Vicente Martínez-Vizcaíno, Maribel Lucerón-Lucas-Torres |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Duchenne muscular dystrophy
Pharmaceutical Science Review Biology polymorphism TGFβ Pharmacy and materia medica systematic review Polymorphism (computer science) Drug Discovery Genotype parasitic diseases medicine Haplotype Transforming growth factor beta medicine.disease Phenotype meta-analysis RS1-441 LTBP4 Transforming growth factor beta binding Meta-analysis Immunology biology.protein Molecular Medicine Medicine SPP1 |
| Zdroj: | Pharmaceuticals, Vol 14, Iss 798, p 798 (2021) Pharmaceuticals |
| ISSN: | 1424-8247 2835-7094 |
| Popis: | The transforming growth factor beta (TGFβ) pathway could modulate the Duchenne muscular dystrophy (DMD) phenotype. This meta-analysis aims to estimate the association of genetic variants involved in the TGFβ pathway, including the latent transforming growth factor beta binding protein 4 (LTBP4) and secreted phosphoprotein 1 (SPP1) genes, among others, with age of loss of ambulation (LoA) and cardiac function in patients with DMD. Meta-analyses were conducted for the hazard ratio (HR) of LoA for each genetic variant. A subgroup analysis was performed in patients treated exclusively with glucocorticoids. Eight studies were included in the systematic review and four in the meta-analyses. The systematic review suggests a protective effect of LTBP4 haplotype IAAM (recessive model) for LoA. It is also suggested that the SPP1 rs28357094 genotype G (dominant model) is associated with early LoA in glucocorticoids-treated patients. The meta-analysis of the LTBP4 haplotype IAAM showed a protective association with LoA, with an HR = 0.78 (95% CI: 0.67–0.90). No association with LoA was observed for the SPP1 rs28357094. The LTBP4 haplotype IAAM is associated with a later LoA, especially in the Caucasian population, while the SPP1 rs28357094 genotype G could be associated with a poor response to glucocorticoids. Future research is suggested for SPP1 rs11730582, LTBP4 rs710160, and THBS1 rs2725797. |
| Databáze: | OpenAIRE |
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