New kid on the block: lipid droplets in the nucleus
| Autor: | Antonio Daniel Barbosa, Symeon Siniossoglou |
|---|---|
| Přispěvatelé: | Siniossoglou, Symeon [0000-0001-5424-5466], Apollo - University of Cambridge Repository |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Nuclear Envelope lipid droplet Saccharomyces cerevisiae Endoplasmic Reticulum Models Biological Biochemistry 03 medical and health sciences 0302 clinical medicine lipid Lipid droplet Organelle medicine Animals Homeostasis Humans Inner membrane Nuclear membrane Molecular Biology Cell Nucleus Chemistry Endoplasmic reticulum nucleus Lipid Droplets Cell Biology Lipid Metabolism Cell biology nuclear membrane 030104 developmental biology medicine.anatomical_structure Cytoplasm 030220 oncology & carcinogenesis Membrane biogenesis lipids (amino acids peptides and proteins) Nucleus |
| Zdroj: | The FEBS Journal. 287:4838-4843 |
| ISSN: | 1742-4658 1742-464X |
| DOI: | 10.1111/febs.15307 |
| Popis: | The regulation of lipid homeostasis is essential for normal cell physiology, and its disruption can lead to disease. Lipid droplets (LDs) are ubiquitous organelles dedicated to storing nonpolar lipids that are used for metabolic energy production or membrane biogenesis. LDs normally emerge from, and associate with, the endoplasmic reticulum and interact with other cytoplasmic organelles to deliver the stored lipids. Recently, LDs were found to reside also at the inner side of the nuclear envelope and inside the nucleus in yeast and mammalian cells. This unexpected finding raises fundamental questions about the nature of the inner nuclear membrane, its connection with the endoplasmic reticulum and the pathways of LD formation. In this viewpoint, we will highlight recent developments relating to these questions and discuss possible roles of LDs in nuclear physiology. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |