An In Vivo Confocal Microscopic Study of Corneal Nerve Morphology in Unilateral Keratoconus
| Autor: | Harsha Nagaraja, Rudy M.M.A. Nuijts, Chaitra Jayadev, Arkasubhra Ghosh, Natasha Pahuja, Aarti Agrawal, Rohit Shetty |
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| Přispěvatelé: | Oogheelkunde, RS: MHeNs - R3 - Neuroscience, MUMC+: *AB Refractie Chirurgie Oogheelkunde (9), MUMC+: MA UECM Oogartsen MUMC (9) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Keratoconus medicine.medical_specialty Morphology (linguistics) Article Subject genetic structures Corneal nerve Confocal lcsh:Medicine General Biochemistry Genetics and Molecular Biology Cornea 03 medical and health sciences 0302 clinical medicine Nerve Fibers In vivo Ophthalmology medicine Humans Plexus Microscopy Confocal General Immunology and Microbiology business.industry lcsh:R General Medicine Middle Aged medicine.disease eye diseases medicine.anatomical_structure 030221 ophthalmology & optometry Female sense organs Fiber density business 030217 neurology & neurosurgery Research Article |
| Zdroj: | BioMed Research International, Vol 2016 (2016) BioMed Research International BioMed Research International, 2016:5067853. Hindawi Publishing Corporation |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | Purpose.To study the corneal nerve morphology and its importance in unilateral keratoconus.Materials and Methods.In this prospective cross-sectional study, 33 eyes of 33 patients with keratoconus in one eye (Group 3) were compared with the other normal eye of the same patients (Group 2) and 30 eyes of healthy patients (Group 1). All patients underwent detailed ophthalmic examination followed by topography with Pentacam HR and in vivo confocal microscopy (IVCM). Five images obtained with IVCM were analyzed using an automated CCmetrics software version 1.0 for changes in subbasal plexus of nerves.Results.Intergroup comparison showed statistically significant reduction in corneal nerve fiber density (CNFD) and length (CNFL) in Group 3 as compared to Group 1 (p<0.001andp=0.001, resp.) and Group 2 (p=0.01andp=0.02, resp.). Though corneal nerve fiber length, diameter, area, width, corneal nerve branch density, and corneal total branch density were found to be higher in decentered cones, only the corneal nerve branch density (CNBD) was found to be statistically significant (p<0.01) as compared to centered cones.Conclusion.Quantitative changes in the corneal nerve morphology can be used as an imaging marker for the early diagnosis of keratoconus before the onset of refractive or topography changes. |
| Databáze: | OpenAIRE |
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