Osteoporosis in Male Hypogonadism: Responses to Androgen Substitution Differ among Men with Primary and Secondary Hypogonadism
| Autor: | Markus Schubert, Wilhelm Krone, T Minnemann, Christoph Reiners, Friedrich Jockenhövel, Catharina Bullmann |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Hormone Replacement Therapy medicine.drug_class Endocrinology Diabetes and Metabolism Osteoporosis law.invention Endocrinology Double-Blind Method Randomized controlled trial Bone Density law Internal medicine Mesterolone Humans Medicine Testosterone Prospective Studies Aged Drug Implants Bone mineral Estradiol business.industry Male hypogonadism Hypogonadism Dihydrotestosterone Middle Aged Androgen medicine.disease Pediatrics Perinatology and Child Health Androgens Steroids business |
| Zdroj: | Hormone Research in Paediatrics. 60:21-28 |
| ISSN: | 1663-2826 1663-2818 |
| DOI: | 10.1159/000070823 |
| Popis: | Background: No randomized study exists comparing the effects of different modes of androgen substitution on bone mineral density (BMD). Methods: We performed a prospective, randomized, trial assigning 53 hypogonadal men to the following treatment groups: mesterolone 100 mg p.o. daily, testosterone undecanoate 160 mg p.o. daily, testosterone enanthate 250 mg i.m. every 21 days, or a single subcutaneous implantation of 1,200 mg crystalline testosterone. The BMD was determined by peripheral quantitative computed tomography. Results: At baseline, men with secondary hypogonadism (n = 33) had a lower BMD (–1.52 ± 0.23 SDS; Z-scores) than men with primary hypogonadism (n = 20, –0.87 ± 0.23 SDS, p < 0.01). In men with primary hypogonadism, the BMD increased dose dependently (crystalline testosterone +7.0 ± 1.3%, testosterone enanthate +4.8 ± 0.2%, testosterone undecanoate +3.4 ± 2.5%, mesterolone +0.8 ± 1.6%) after 6 months of therapy. Only secondary hypogonadal men treated with testosterone enanthate experienced an increase of the BMD. Conclusions: In primary hypogonadal men the BMD responds dose dependently to testosterone substitution, whereas in secondary hypogonadism only testosterone enanthate treatment significantly increased the BMD. |
| Databáze: | OpenAIRE |
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