Novel therapeutic approaches for chronic kidney disease due to glomerular disorders
| Autor: | Caroline B. Marshall, Camille Macé, Hector Donoro-Blazquez, María del Nogal-Avila, Lionel C. Clement, Sumant S. Chugh, Manish K. Saha |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Physiology Kidney Glomerulus Pharmacology 03 medical and health sciences Immune system In vivo medicine Angiopoietin-Like Protein 4 Animals Humans Glomerular disease Renal Insufficiency Chronic Proteinuria business.industry medicine.disease Urokinase receptor Clinical trial 030104 developmental biology medicine.symptom business Angiopoietins Kidney disease Perspectives |
| Popis: | Improved understanding of glomerular disease mechanisms over the past decade has led to the emergence of new and targeted therapeutic strategies for chronic kidney disease (CKD). Most promising among these are the administration of recombinant mutated human angiopoietin-like 4, sialic acid-related sugars that induce sialylation in vivo, compounds related to Bis-T-23, and immune depletion of the soluble urokinase receptor from the circulation. Taking these therapeutic strategies into clinical trials will be the first step away from repurposed and relatively toxic drugs currently used for treating kidney disease. |
| Databáze: | OpenAIRE |
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