Hormone-Sensitive Gene Signatures in the Mammary Epithelial Cells of Lactating Women With Persistent Low Milk Production
| Autor: | Erin Wagner, Sarah W. Riddle, Amy Thompson, Laurie A. Nommsen-Rivers, Laura P. Ward, Rebekah Karns, Josephine F. Trott, Russell C. Hovey, Katherine Bernardo |
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| Rok vydání: | 2021 |
| Předmět: |
Maternal
Perinatal and Pediatric Nutrition Nutrition and Dietetics Prolactin receptor Medicine (miscellaneous) Biology Prolactin Andrology chemistry.chemical_compound medicine.anatomical_structure chemistry Downregulation and upregulation Lactation Gene expression medicine Lactose Gene Food Science Hormone |
| Zdroj: | Curr Dev Nutr |
| ISSN: | 2475-2991 |
| Popis: | OBJECTIVES: Insulin resistance may contribute to the association between maternal obesity and lactation difficulties. Our objective was to examine differential expression of genes involved in insulin-sensitive and prolactin-sensitive signaling in the mammary glands of women with very low, versus sufficient, milk production. METHODS: Among a subset of mothers in a study of low milk supply, extracellular mammary epithelial cell mRNA was isolated from fresh milk fat and submitted for RNA-sequencing. Aligned and quantified reads were examined for differentially expressed genes by t-test (DEG, p |
| Databáze: | OpenAIRE |
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