加齢による歯周組織中の酸化ストレスに対するコーヒー摂取の効果の検討
| Autor: | Tetsuji Azuma, Hisataka Miyai, Manabu Morita, Takayuki Maruyama, Toshiki Yoneda, Daisuke Ekuni, Takaaki Tomofuji, Terumasa Kobayashi |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Periodontium Aging Cancer Research Periodontal tissue Baseline group antioxidant Antioxidant NF-E2-Related Factor 2 medicine.medical_treatment coffee Drinking Physiology Chromosomal translocation medicine.disease_cause Antioxidants General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Coffee intake medicine Animals oxidative stress Dental alveolus Pharmacology business.industry Immunohistochemistry Rats Powdered food 030220 oncology & carcinogenesis periodontal tissue business Biomarkers Oxidative stress Research Article |
| Popis: | Background/aim: The purpose of this study was to determine the anti-aging effects of coffee intake on oxidative stress in rat periodontal tissue and alveolar bone loss. Materials and methods: Male Fischer 344 rats (8 weeks old) were randomized to four groups; the baseline group immediately sacrificed, the control group fed with normal powdered food for 8 weeks, and the experimental groups fed with powdered food containing 0.62% or 1.36% coffee components for 8 weeks. Results: Alveolar bone loss and gingival level of 8-hydroxydeoxyguanosine were significantly lower in the 1.36% coffee group than in the control group. Nuclear factor erythroid 2-related factor 2 translocation to the nucleus was significantly higher in the 1.36% coffee group than in the control group. Conclusion: Continuous intake of 1.36% coffee could prevent age-related oxidative stress in the periodontal tissue and alveolar bone loss, possibly by up-regulating the Nrf2 signaling pathway. |
| Databáze: | OpenAIRE |
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