Cyclopropanation–ring expansion of 3-chloroindoles with α-halodiazoacetates: novel synthesis of 4-quinolone-3-carboxylic acid and norfloxacin
| Autor: | Pal Rongved, Tore Bonge-Hansen, Sara Peeters, Linn Neerbye Berntsen |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Antibiotic drug
Letter medicine.drug_class Cyclopropanation cyclopropanation 4-quinolone-3-carboxylic acid 010402 general chemistry Ring (chemistry) rh(ii) 01 natural sciences Catalysis lcsh:QD241-441 quinolone lcsh:Organic chemistry medicine norfloxacin quinoline lcsh:Science Norfloxacin Indole test catalysis 010405 organic chemistry Chemistry Organic Chemistry Quinolone Combinatorial chemistry 0104 chemical sciences indole ring expansion lcsh:Q medicine.drug |
| Zdroj: | Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 2156-2160 (2019) Beilstein Journal of Organic Chemistry |
| ISSN: | 1860-5397 2195-951X |
| DOI: | 10.3762/bjoc.15.212 |
| Popis: | We present a short and efficient way of synthesizing two synthetically versatile 4-quinolone-3-carboxylate building blocks by cyclopropanation-ring expansion of 3-chloroindoles with α-halodiazoacetates as the key step. This novel transformation was applied towards the synthesis of the antibiotic drug norfloxacin. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|