High-throughput multiplexed capillary electrophoresis in drug discovery
| Autor: | Ho-ming Pang, Shelley J Coldiron, Jeremy R Kenseth |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Pharmacology
Profiling (computer programming) Chromatography Chemistry Drug discovery Microfluidics Electrophoresis Capillary Nanotechnology Microfluidic Analytical Techniques Metabolite analysis Multiplexing Business process discovery Capillary electrophoresis Drug Design Drug Discovery Technology Pharmaceutical Throughput (business) |
| Zdroj: | Drug Discovery Today. 9:1072-1080 |
| ISSN: | 1359-6446 |
| Popis: | The demand for high-throughput analytical tools to support drug discovery applications has led to the development of multiplexed capillary electrophoresis and multichannel microfluidic devices to characterize libraries of compounds and alleviate backlogs in the discovery process. The capability to analyze multiple samples in parallel, and the diverse separation conditions that are permissible, facilitates rapid turnaround times. Examples of high-throughput applications of multiplexed electrophoresis in drug discovery include: physicochemical profiling, enzyme analysis, chiral separations and protein/metabolite analysis. Many single capillary electrophoresis methods can be potentially adapted to a multiplexed format, therefore, we anticipate the development of other high-throughput applications in the near future, which should facilitate decreases in sample analysis time and help improve laboratory efficiency. |
| Databáze: | OpenAIRE |
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