Skin ‑ a vast organ with immunological function (Review)
| Autor: | Nicoleta Dima, Minela Aida Maranduca, Daniel Constantin Branisteanu, D N Serban, Daciana Elena Branisteanu, Loredana Liliana Hurjui, Ionela Lacramioara Serban |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research integumentary system business.industry Cell Inflammation Review General Medicine Vitiligo Atopic dermatitis medicine.disease 03 medical and health sciences Pemphigus 030104 developmental biology 0302 clinical medicine Immune system medicine.anatomical_structure Immunology and Microbiology (miscellaneous) 030220 oncology & carcinogenesis Psoriasis Immunology medicine medicine.symptom business Keratinocyte |
| Zdroj: | Exp Ther Med |
| ISSN: | 1792-1015 1792-0981 |
| DOI: | 10.3892/etm.2020.8619 |
| Popis: | The skin is an organ with multiple functions, where important inflammatory and immunological processes take place. The integrity of the skin barrier is necessary for it to fulfill its roles. An intact skin barrier requires a physiological keratinization process, but also a normal cutaneous microbial flora. Any change in the proliferation and differentiation of keratinocytes entails the disruption of the skin barrier and the triggering of inflammatory and immunological processes at this level, in response to the aggression of external pathogens. Also, there are several specialised immune cells in the skin (Langerhans cells, T regulator cells, T helper cells), that maintain a balance between pro-inflammatory and anti-inflammatory processes at this level. Disturbing the immune homeostasis causes inflammation and allergic skin reaction. Psoriasis and atopic dermatitis are two inflammatory diseases of the skin, characterized by perturbation of the mechanisms of skin barrier formation. The immune system of the skin is also involved in the pathophysiology of vitiligo and pemphigus. The aim of this review is to offer a brief presentation of the inflammatory and immunological processes that occur in the skin. |
| Databáze: | OpenAIRE |
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