Rare suprasellar glioblastoma: report of two cases and review of the literature

Autor: Elisabeth J. Rushing, René-Ludwig Bernays, Ingeborg Fischer, Francine Hehn de Oliveira, Doreen Lemm, Ralf A. Kockro, Spyros Kollias
Přispěvatelé: University of Zurich, Lemm, Doreen
Rok vydání: 2011
Předmět:
Male
Cancer Research
medicine.medical_specialty
Pathology
Neurology
Skull Neoplasms
10208 Institute of Neuropathology
Vision Disorders
610 Medicine & health
Neurosurgical Procedures
Fatal Outcome
10043 Clinic for Neuroradiology
Glial Fibrillary Acidic Protein
medicine
Humans
1306 Cancer Research
DNA Modification Methylases
Aged
medicine.diagnostic_test
business.industry
Tumor Suppressor Proteins
Magnetic resonance imaging
General Medicine
Middle Aged
medicine.disease
Anisocoria
Immunohistochemistry
Craniopharyngioma
Isocitrate Dehydrogenase
Paresis
2728 Neurology (clinical)
DNA Repair Enzymes
Ki-67 Antigen
Oncology
570 Life sciences
biology
2730 Oncology
Female
Neurology (clinical)
Neurosurgery
Progressive visual impairment
Differential diagnosis
Headaches
medicine.symptom
Hypothalamic Neoplasms
business
Glioblastoma
Zdroj: Brain tumor pathology. 29(4)
ISSN: 1861-387X
Popis: Background and importance: The suprasellar and hypothalamic/chiasmatic regions can harbor a broad range of pathologic conditions, both neoplastic and nonneoplastic; however, malignant gliomas are extremely rare in those regions. Clinical presentations: Patient 1 was a 70year-old man with weight loss and rapidly progressive visual impairment. A mass centered in the hypothalamus was detected on magnetic resonance (MR) imaging. The second patient, a 45year-old woman, complained of visual symptoms and headaches. MR imaging revealed a combined intra- and suprasellar mass. In both instances, the preoperative differential diagnosis favored craniopharyngioma. Histological examination confirmed the diagnosis of glioblastoma. Conclusion: We report two rare adult cases of hypothalamic/chiasmatic glioblastoma. The authors review the literature, highlighting the importance of considering this rare entity in the differential diagnosis of suprasellar and hypothalamic lesions
Databáze: OpenAIRE
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